Research ArticleCROHN’S DISEASE

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

See allHide authors and affiliations

Science Translational Medicine  10 Jan 2018:
Vol. 10, Issue 423, eaai7795
DOI: 10.1126/scitranslmed.aai7795

Article Information

vol. 10 no. 423

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication August 11, 2016
  • Resubmitted March 31, 2017
  • Accepted for publication July 18, 2017
  • .

Author Information

  1. Ken Y. Hui1,2,
  2. Heriberto Fernandez-Hernandez3,
  3. Jianzhong Hu3,
  4. Adam Schaffner4,5,
  5. Nathan Pankratz6,
  6. Nai-Yun Hsu3,
  7. Ling-Shiang Chuang3,
  8. Shai Carmi7,
  9. Nicole Villaverde3,
  10. Xianting Li4,
  11. Manual Rivas8,9,
  12. Adam P. Levine10,
  13. Xiuliang Bao3,
  14. Philippe R. Labrias3,
  15. Talin Haritunians11,
  16. Darren Ruane12,
  17. Kyle Gettler1,13,
  18. Ernie Chen3,
  19. Dalin Li11,
  20. Elena R. Schiff10,
  21. Nikolas Pontikos10,
  22. Nir Barzilai14,
  23. Steven R. Brant15,16,
  24. Susan Bressman17,
  25. Adam S. Cheifetz18,
  26. Lorraine N. Clark19,20,
  27. Mark J. Daly8,9,21,22,
  28. Robert J. Desnick3,
  29. Richard H. Duerr23,24,
  30. Seymour Katz25,26,27,
  31. Todd Lencz28,
  32. Richard H. Myers29,
  33. Harry Ostrer30,
  34. Laurie Ozelius3,31,
  35. Haydeh Payami32,33,
  36. Yakov Peter34,35,
  37. John D. Rioux36,37,
  38. Anthony W. Segal10,
  39. William K. Scott38,
  40. Mark S. Silverberg39,40,
  41. Jeffery M. Vance38,
  42. Iban Ubarretxena-Belandia5,
  43. Tatiana Foroud41,
  44. Gil Atzmon14,42,
  45. Itsik Pe’er43,
  46. Yiannis Ioannou3,
  47. Dermot P. B. McGovern11,
  48. Zhenyu Yue4,
  49. Eric E. Schadt3,44,45,
  50. Judy H. Cho1,3,13,46,* and
  51. Inga Peter3,44,*,
  1. 1Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
  2. 2Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
  3. 3Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  4. 4Departments of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  5. 5Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  6. 6Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
  7. 7Braun School of Public Health and Community Medicine, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
  8. 8Department of Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
  9. 9Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
  10. 10Centre for Molecular Medicine, Division of Medicine, University College, London WC1E 6JF, UK.
  11. 11Translational Genomics Group, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  12. 12Department of Immunology and Inflammation, Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.
  13. 13Department of Genetics, Yale University, New Haven, CT 06520, USA.
  14. 14Departments of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  15. 15Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
  16. 16Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21231, USA.
  17. 17Alan and Barbara Mirken Department of Neurology, Beth Israel Medical Center, New York, NY 10003, USA.
  18. 18Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  19. 19Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.
  20. 20Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.
  21. 21Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  22. 22Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
  23. 23Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  24. 24Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.
  25. 25New York University School of Medicine, New York City, NY 10016, USA.
  26. 26North Shore University-Long Island Jewish Medical Center, Manhasset, NY, USA.
  27. 27St. Francis Hospital, Roslyn, NY 11576, USA.
  28. 28Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA.
  29. 29Department of Neurology, Boston University School of Medicine, Boston, MA 02114, USA.
  30. 30Departments of Pathology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
  31. 31Deparment of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
  32. 32Departments of Neurology and Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  33. 33HudsonAlpha Institute for Biotechnology, Huntsville, AL 35805, USA.
  34. 34Department of Biology, Touro College, Queens, NY 10033, USA.
  35. 35Department of Pulmonary Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10033, USA.
  36. 36Research Center, Montreal Heart Institute, Montreal, Quebec H1T1C8, Canada.
  37. 37Faculté de Médecine, Université de Montréal, Montreal, Quebec H1T1C8, Canada.
  38. 38Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  39. 39Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T3L9, USA.
  40. 40Department of Medicine, University of Toronto, Toronto, Ontario M5G1X5, Canada.
  41. 41Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  42. 42Faculty of Natural Sciences, University of Haifa, Haifa 3498838, Israel.
  43. 43Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10032, USA.
  44. 44Institute for Genetics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  45. 45Sema4, a Mount Sinai venture, Stamford, CT 06902, USA.
  46. 46Section of Gastroenterology and Hepatology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
  1. Corresponding author. Email: inga.peter{at}mssm.edu
    • * These authors contributed equally to this work.

    Altmetric

    Article usage

    Article usage: January 2018 to March 2021

    AbstractFullPdf
    Jan 20181183317482790
    Feb 20182245124247
    Mar 201888454138
    Apr 201871470125
    May 201885851100
    Jun 20187704276
    Jul 20182923756
    Aug 20183458558
    Sep 20182966240
    Oct 20183089442
    Nov 201845412947
    Dec 20185738536
    Jan 201978429104
    Feb 20199407294
    Mar 20193438246
    Apr 20195373146
    May 20196240119
    Jun 2019222690
    Jul 2019328795
    Aug 2019224597
    Sep 20192183111
    Oct 2019421181
    Nov 2019121889
    Dec 2019221657
    Jan 2020223779
    Feb 2020616179
    Mar 20202203141
    Apr 20201147108
    May 20208170127
    Jun 2020118782
    Jul 20201123145
    Aug 2020218397
    Sep 20201315668
    Oct 2020217292
    Nov 2020413064
    Dec 2020412357
    Jan 2021520899
    Feb 2021212671
    Mar 202123629

    Stay Connected to Science Translational Medicine

    Navigate This Article