10 January 2018
Vol 10, Issue 423

About The Cover

Cover image expansion

ONLINE COVER Genetics Connects Gut and Brain. A genome-wide association analysis of patients with the inflammatory bowel disorder Crohn's disease (CD) and healthy control individuals identified two functional variants in the LRRK2 gene that conferred either risk or protection for CD (Hui et al.). Mutations in LRRK2 (the structure of which is shown) are known to be associated with Parkinson's disease (PD), a neurodegenerative disorder. Analysis of the LRRK2 locus in a large cohort of 24,570 individuals revealed similar genetic effects between CD and PD, providing insights into common pathogenic mechanisms for these two seemingly unrelated diseases. [CREDIT: JILL K. GREGORY/MOUNT SINAI HEALTH SYSTEM]