Contents
03 January 2018
Vol 10, Issue 422
Vol 10, Issue 422
Research Articles
- Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade
Intravenous infusion of oncolytic reovirus in patients leads to infection of brain tumors, infiltration by cytotoxic T cells, and up-regulation of PD-L1.
- Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy
Maraba virus treatment before surgery for triple-negative breast cancer promotes antitumor immunity.
- A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
A miRNA181a/NFAT5 signaling axis promotes immune activation and interferes with the induction of regulatory T cells in islet autoimmunity.
- Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans
Noninvasive bimodal auditory stimulation targets the dorsal cochlear nucleus and reduces tinnitus in guinea pigs and humans.
Report
- Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis
Repeat cycles of miridesap, to deplete circulating serum amyloid P component (SAP), followed by the anti-SAP antibody, dezamizumab, cleared visceral amyloid deposits in patients with systemic amyloidosis.
Review
- Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Targeting extracellular matrix stiffness holds clinical potential to attenuate pathological progression in the emerging field of mechanomedicine.
Editors' Choice
- TOR at the core of impaired regeneration
Repeated activation of target of rapamycin (TOR) signaling during tissue regeneration results in impaired stem cell maintenance and promotes aging.
- Novel drug combination unleashes apoptosis in AML
The combination of p53 activation and Bcl-2 inhibition reciprocally overcomes apoptosis resistance and leads to synergistic efficacy in acute myeloid leukemia.
- Adolescent obesity thwarts lifelong sleep
Obesity during adolescence shapes lifelong sleep circuitry via serotonin.
About The Cover
ONLINE COVER Cancer Immunotherapy Going Viral. This image shows infection of a tumor by an oncolytic virus (blue), which kills cancer cells, releasing tumor antigens (green). These antigens are taken up by antigen-presenting cells (turquoise) and presented to T cells (purple nucleus). The T cells prepare to kill tumor cells but can be inactivated (gray nucleus) by binding of an immune checkpoint inhibitory receptor (turquoise) to its ligand (pink) on cancer cells. Immune checkpoint blocking antibodies (green) allow T cells to kill the cancer cells. Bourgeois-Daigneault, Samson and their colleagues show how oncolytic virus treatment improves the efficacy of subsequent immune checkpoint blockade against different cancer types. [CREDIT: CHRISTINE KENNEY/C. KENNEY ILLUSTRATION]