Researching Genetic Versus Nongenetic Determinants of Disease: A Comparison and Proposed Unification

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Science Translational Medicine  18 Nov 2009:
Vol. 1, Issue 7, pp. 7ps8
DOI: 10.1126/scitranslmed.3000247

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Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.


  • Citation: J. P. A. Ioannidis, E. Y. Loy, R. Poulton, K. S. Chia, Researching genetic versus nongenetic determinants of disease: A comparison and proposed unification. Sci. Transl. Med. 1, 7ps8 (2009).

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