Gut Check: Testing a Role for the Intestinal Microbiome in Human Obesity

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Science Translational Medicine  11 Nov 2009:
Vol. 1, Issue 6, pp. 6ps7
DOI: 10.1126/scitranslmed.3000483

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By using germ-free mice transplanted with human fecal microbiota, scientists show that a high-fat, high-sugar diet durably changes the transplanted microbiome and that this diet-altered microbiome promotes obesity. This model should encourage investigation of the gut microbiome as a contributor to human metabolic disease and permit discovery of targets for the prevention and treatment of these disorders.


  • Citation: J. S. Flier, J. J. Mekalanos, Gut check: Testing a role for the intestinal microbiome in human obesity. Sci. Transl. Med. 1, 6ps7 (2009).

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