Contents
Vol 1, Issue 6
Contents
Perspectives
- Regulatory Considerations for Translating Gene Therapy: A European Union Perspective
A preclinical gene therapy study in nonhuman primates is discussed with a view to European regulatory requirements for first clinical use.
- Gut Check: Testing a Role for the Intestinal Microbiome in Human Obesity
Germ-free mice transplanted with human fecal microbiota may promote investigation of the gut microbiome as a contributor to human disease and permit the discovery of targets for the prevention and treatment of these disorders.
Research Articles
- The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
A translational medicine pipeline is described where human gut microbial communities and diets are re-created in gnotobiotic mice and the impact on microbe and host is defined using metagenomics.
- Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates
A vector delivered into muscles of monkeys generates a natural regulatory molecule, which increases muscle size and strength and may be useful therapeutically.
Editors' Choice
- Heart Valve Job
Bovine pericardium impregnated with cell-attracting proteins becomes engrafted with cells when used as replacement heart valves in sheep, functioning well for at least 5 months.
- Targeting the Tumor Microenvironment
A Stat3-stifling siRNA augmented with an oligonucleotide agonist of a Toll-like receptor stimulates tumor-destroying immune responses.
- Dangerous Liaison
HIV-1 sticks to sperm and facilitates transmission of the virus to immune cells.
- Reducing the Effects of Diabetes
A transcription factor that responds to low oxygen improves blood vessel formation after ischemia.
