Research ArticleGenetics

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

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Science Translational Medicine  04 Nov 2009:
Vol. 1, Issue 5, pp. 5ra11
DOI: 10.1126/scitranslmed.3000237

Article Information

vol. 1 no. 5 5ra11

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 29, 2009
  • Accepted for publication October 16, 2009
  • .

Author Information

  1. Hirotaka Matsuo1,*,
  2. Tappei Takada2,
  3. Kimiyoshi Ichida3,4,
  4. Takahiro Nakamura5,6,
  5. Akiyoshi Nakayama1,7,
  6. Yuki Ikebuchi2,
  7. Kousei Ito2,
  8. Yasuyoshi Kusanagi1,
  9. Toshinori Chiba1,
  10. Shin Tadokoro1,
  11. Yuzo Takada8,
  12. Yuji Oikawa9,
  13. Hiroki Inoue1,
  14. Koji Suzuki10,
  15. Rieko Okada11,
  16. Junichiro Nishiyama12,
  17. Hideharu Domoto13,
  18. Satoru Watanabe14,
  19. Masanori Fujita14,
  20. Yuji Morimoto1,
  21. Mariko Naito11,
  22. Kazuko Nishio11,
  23. Asahi Hishida11,
  24. Kenji Wakai11,
  25. Yatami Asai15,
  26. Kazuki Niwa9,
  27. Keiko Kamakura16,
  28. Shigeaki Nonoyama17,
  29. Yutaka Sakurai18,
  30. Tatsuo Hosoya4,
  31. Yoshikatsu Kanai19,
  32. Hiroshi Suzuki2,
  33. Nobuyuki Hamajima11 and
  34. Nariyoshi Shinomiya1
  1. 1Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  2. 2Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Tokyo 113-8655, Japan.
  3. 3Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan.
  4. 4Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo 105-8461, Japan.
  5. 5Laboratory for Mathematics, Premedical Course, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  6. 6Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Tokyo 108-8639, Japan.
  7. 7Medical Platoon, 9th Aircraft Control and Warning Squadron, Japan Air Self-Defense Force, Satsuma-Sendai, Kagoshima 896-1411, Japan.
  8. 8Department of Forensic Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  9. 9Department of Biology, Faculty of Science, Toho University, Funabashi, Chiba 274-8510, Japan.
  10. 10Department of Public Health, Fujita Health University, School of Health Sciences, Toyoake, Aichi 470-1192, Japan.
  11. 11Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
  12. 12Japan Self-Defense Forces Hospital Yokosuka, Yokosuka, Kanagawa 237-0071, Japan.
  13. 13Medical Service Unit Kure, Japan Maritime Self-Defense Force, Kure, Hiroshima 737-8554, Japan.
  14. 14Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa, Saitama 359-8513, Japan.
  15. 15Seirei Social Welfare Community, Hamamatsu, Shizuoka 430-0946, Japan.
  16. 16Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  17. 17Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  18. 18Department of Preventive Medicine and Public Health, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
  19. 19Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.
  1. *To whom correspondence should be addressed. E-mail: hmatsuo{at}ndmc.ac.jp

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