04 November 2009
Vol 1, Issue 5

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ONLINE COVER Fibrosis in mouse kidney. Ischemic injury to mouse kidney results in severe fibrosis, as shown here by the deposition of collagen (stained with Sirius red). Treatment with human serum amyloid protein decreases fibrosis by reducing the number of monocytes and macrophages in the kidney. The process is dependent on FcγR and the cytokine IL-10, as described in the paper by Castaño et al. in this issue. [Adapted from Fig. 2 in Castaño et al., p. 5ra13]