Research ArticleGene Therapy

Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia

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Science Translational Medicine  14 Oct 2009:
Vol. 1, Issue 2, pp. 2ra4
DOI: 10.1126/scitranslmed.3000130

Article Information

vol. 1 no. 2 2ra4

PubMed: 
Print ISSN: 
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History: 
  • Received May 7, 2009
  • Accepted September 25, 2009
  • .

Author Information

  1. Béchir Jarraya1,2,3,4,*,
  2. Sabrina Boulet1,2,,
  3. G. Scott Ralph5,,
  4. Caroline Jan1,2,
  5. Gilles Bonvento1,2,
  6. Mimoun Azzouz6,
  7. James E. Miskin5,
  8. Masahiro Shin1,2,
  9. Thierry Delzescaux1,2,
  10. Xavier Drouot3,7,
  11. Anne-Sophie Hérard1,2,
  12. Denise M. Day5,
  13. Emmanuel Brouillet1,2,
  14. Susan M. Kingsman5,
  15. Philippe Hantraye1,2,
  16. Kyriacos A. Mitrophanous5,*,
  17. Nicholas D. Mazarakis8 and
  18. Stéphane Palfi1,2,3,4,*
  1. 1CEA, DSV, I²BM, Molecular Imaging Research Center (MIRCen), F-92265 Fontenay-aux-Roses, France.
  2. 2CEA, CNRS URA 2210, F-92265 Fontenay-aux-Roses, France.
  3. 3Universite Paris 12, Faculte de Medecine, F-94010 Creteil, France.
  4. 4AP-HP, Groupe Henri-Mondor Albert-Chenevier, UF Neurochirurgie Fonctionnelle, F-94010 Creteil, France.
  5. 5Oxford BioMedica Ltd., Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK.
  6. 6Neurology Unit, Medical School, Sheffield University, Sheffield S10 2RX, UK.
  7. 7AP-HP, Groupe Henri-Mondor Albert-Chenevier, Service de Neurophysiologie, F-94010 Creteil, France.
  8. 8Department of Gene Therapy, Division of Medicine, Imperial College London, St Mary’s Campus, London W2 1PG, UK.
  1. *To whom correspondence should be addressed. E-mail: stephane.palfi{at}hmn.aphp.fr (S.P.); bechir.jarraya{at}cea.fr (B.J.); K.Mitrophanous{at}oxfordbiomedica.co.uk (K.A.M.)

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