Contents
Vol 1, Issue 2
Contents
Commentary
- More Than Baby Steps: Perspectives on Pediatric Translational Research
The challenges of product development and the unique issues that pertain to pediatric research represent both obstacles to and opportunities for the translation of scientific knowledge into advancements in pediatric clinical medicine.
Perspectives
- Gene Therapy for Dopamine Replacement in Parkinson´s Disease
A gene therapy approach aimed at restoring dopamine synthesis in the brain has proven efficacious in a nonhuman primate model of Parkinson's disease.
- Arvid Carlsson: An Early Pioneer in Translational Medicine
More than half a century ago, Swedish scientist Arvid Carlsson performed basic research that was rapidly translated into the first treatment for Parkinson's disease.
Research Articles
- Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia
A gene therapy approach for the treatment of Parkinson’s disease.
- Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria: Implications for Vaccine Development
Children from Mali who are repeatedly infected with malaria are more likely to get sick if the parasite is highly variable, a possible obstacle to an effective vaccine.
- Arrhythmia in Heart and Brain: KCNQ1 Mutations Link Epilepsy and Sudden Unexplained Death
Mice engineered to carry a human mutation that causes heart problems also have epilepsy, suggesting a cause of SUDEP, sudden unexplained death in epilepsy.
Editor's Choice
- Keys to Safer Transfusions
Patients with activated immune systems may be prone to the acute lung injury sometimes seen after transfusions, but platelet-directed therapies may help.
- New Target for Anti-Leukemia Attack
Complementary proteomic and genetic experiments identify a possible therapeutic strategy for acute myeloid leukemia.
- Metabolic Barcode: With or Without You, Genome
A new method based on a high-throughput array reveals metabolites and functionally characterizes proteins in organisms for which no DNA sequence is available.
- Monitoring Methylation
A new technique allows digital quantification of rare methylation events, which could serve as cancer biomarkers in clinical samples.
