Contents
Vol 1, Issue 12
Contents
Perspectives
- PPARγ Activation: A Potential Treatment For Pulmonary Hypertension
Pharmacological activation of the transcription factor PPARγ affects the expression of key genes involved in the development of pulmonary hypertension (PH), subsequently has a variety of beneficial effects in the vasculature, and hence might be a powerful treatment of PH.
- α2A-Adrenergic Receptors in the Genetics, Pathogenesis, and Treatment of Type 2 Diabetes
Genetic variation of α2A-adrenergic receptors on pancreatic β cells provides new avenues for diagnosis and treatment of type 2 diabetes.
Research Article
- Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
Massively parallel sequencing of rearranged immune receptor genes permits detection and tracking of specific immune cell populations in normal and pathological contexts.
Reports
- Seasonal Influenza Vaccine Provides Priming for A/H1N1 Immunization
Tests in ferrets show that the vaccine now used for mass inoculation against H1N1 is more effective when coinjected with an oil-in-water adjuvant and after the animals’ exposure to seasonal flu vaccine.
Editors' Choice
- Amino Acids to the Rescue
Consumption of neurotransmitter precursors improves cognitive performance after brain injury in mice.
- A Protective Genetic Variant for Lungs
Analysis of seven independent groups of subjects uncovers a metalloproteinase variant that protects against lung damage—but only in smokers and people with lung disease.
- Dynamic Duo: Cancer Drugs and the Immune System
In mice with ovarian cancer, treatment with both the drug Doxil and the cytokine interleukin-18 inhibits tumor growth and promotes tumor regression better than either therapy alone.
- Secret Entry for Dendritic Cells
The basement membrane, thought to be a barrier to cell movement, contains flexible perforations that can serve as cellular gateways.
