You are currently viewing the abstract.
View Full TextLog in to view the full text
AAAS login provides access to Science for AAAS members, and access to other journals in the Science family to users who have purchased individual subscriptions.
More options
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
Abstract
The generation of a robust population of memory T cells is critical for effective vaccine and cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent papers have established a new, cell-intrinsic approach in which small molecules target key metabolic and developmental pathways to enhance the formation and maintenance of highly functional CD8+ memory T cells. These findings raise the exciting new possibility of using small molecules, many of which are already approved for human use, for the pharmacologic induction of immunologic memory.
Footnotes
-
↵* These authors contributed equally to this work.
-
Citation: L. Gattinoni, C. A. Klebanoff, N. P. Restifo, Pharmacologic induction of CD8+ T cell memory: Better living through chemistry. Sci. Transl. Med. 1, 11ps12 (2009).
- Copyright © 2009, American Association for the Advancement of Science