Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry

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Science Translational Medicine  16 Dec 2009:
Vol. 1, Issue 11, pp. 11ps12
DOI: 10.1126/scitranslmed.3000302

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The generation of a robust population of memory T cells is critical for effective vaccine and cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent papers have established a new, cell-intrinsic approach in which small molecules target key metabolic and developmental pathways to enhance the formation and maintenance of highly functional CD8+ memory T cells. These findings raise the exciting new possibility of using small molecules, many of which are already approved for human use, for the pharmacologic induction of immunologic memory.


  • * These authors contributed equally to this work.

  • Citation: L. Gattinoni, C. A. Klebanoff, N. P. Restifo, Pharmacologic induction of CD8+ T cell memory: Better living through chemistry. Sci. Transl. Med. 1, 11ps12 (2009).

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