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Abstract
The generation of a robust population of memory T cells is critical for effective vaccine and cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent papers have established a new, cell-intrinsic approach in which small molecules target key metabolic and developmental pathways to enhance the formation and maintenance of highly functional CD8+ memory T cells. These findings raise the exciting new possibility of using small molecules, many of which are already approved for human use, for the pharmacologic induction of immunologic memory.
Footnotes
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↵* These authors contributed equally to this work.
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Citation: L. Gattinoni, C. A. Klebanoff, N. P. Restifo, Pharmacologic induction of CD8+ T cell memory: Better living through chemistry. Sci. Transl. Med. 1, 11ps12 (2009).
- Copyright © 2009, American Association for the Advancement of Science
