Contents

Contents

• Perspectives

  • Pharmacologic Induction of CD8⁺ T Cell Memory: Better Living Through Chemistry

    By Luca Gattinoni, Christopher A. Klebanoff, Nicholas P. Restifo

    Science Translational Medicine16 Dec 2009 : 11ps12 Full AccessRestricted Access

    Drugs already in clinical use can enhance the generation of memory T cells, creating new prospects for T cell–based immunotherapies for infectious diseases and cancer.

    • Abstract
    • Full Text
    • PDF

  • Toward a Systems-Level Analysis of Infection Biology: A New Method for Conducting Genetic Screens in Human Cells

    By Sarah A. Stanley, Deborah T. Hung

    Science Translational Medicine16 Dec 2009 : 11ps13 Full AccessRestricted Access

    A library of loss-of-function alleles generated from a largely haploid human cell line facilitated genome-wide screens designed to interrogate host-pathogen interactions and promote a systems-level understanding of infectious disease.

    • Abstract
    • Full Text
    • PDF

• Research Article

  • Intravenous Hemostat: Nanotechnology to Halt Bleeding

    By James P. Bertram, Cicely A. Williams, Rebecca Robinson, Steven S. Segal, Nolan T. Flynn, Erin B. Lavik

    Science Translational Medicine16 Dec 2009 : 11ra22 Full AccessRestricted Access

    Synthetic platelets composed of functionalized nanoparticles halve bleeding time in a rat injury model and may prove useful in treating human trauma victims.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Protection from Hemoglobin's Dark Side

    By Katrina L. Kelner

    Science Translational Medicine16 Dec 2009 : 11ec39 Full AccessRestricted Access

    A naturally occurring protein that binds hemoglobin protects the brain from damage after a bleeding stroke, offering a potential therapeutic approach.

    • Summary
    • Full Text

  • Metabolites on the Brain

    By Kelly LaMarco

    Science Translational Medicine16 Dec 2009 : 11ec40 Full AccessRestricted Access

    A mutated metabolic enzyme gains a new catalytic activity that may enhance the progression of metastatic brain cancer.

    • Summary
    • Full Text

  • Where to PARK?

    By Lily Khidr

    Science Translational Medicine16 Dec 2009 : 11ec41 Full AccessRestricted Access

    A gene mutated in familial Parkinson's disease is now linked to brain cancer.

    • Summary
    • Full Text