Research ArticleGenetics and Autoimmune Disease

A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

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Science Translational Medicine  09 Dec 2009:
Vol. 1, Issue 10, pp. 10ra21
DOI: 10.1126/scitranslmed.3000278

Article Information

vol. 1 no. 10 10ra21

PubMed: 
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History: 
  • Received July 20, 2009
  • Accepted November 18, 2009
  • .

Author Information

  1. Maja Jagodic1,*,
  2. Celine Colacios2,3,*,
  3. Rita Nohra1,
  4. Anne S. Dejean2,3,
  5. Amennai Daniel Beyeen1,
  6. Mohsen Khademi1,
  7. Audrey Casemayou2,3,
  8. Lucille Lamouroux2,3,
  9. Christine Duthoit2,3,
  10. Olivier Papapietro2,3,
  11. Louise Sjöholm1,
  12. Isabelle Bernard2,3,
  13. Dominique Lagrange2,3,
  14. Ingrid Dahlman1,
  15. Frida Lundmark4,
  16. Annette B. Oturai5,
  17. Helle B. Soendergaard5,
  18. Anu Kemppinen6,
  19. Janna Saarela6,
  20. Pentti J. Tienari7,
  21. Hanne F. Harbo8,
  22. Anne Spurkland9,
  23. Sreeram V. Ramagopalan10,
  24. Dessa A. Sadovnick11,
  25. George C. Ebers10,
  26. Maria Seddighzadeh12,
  27. Lars Klareskog12,
  28. Lars Alfredsson13,
  29. Leonid Padyukov12,
  30. Jan Hillert4,
  31. Michel Clanet2,3,14,
  32. Gilles Edan15,
  33. Bertrand Fontaine16,17,18,
  34. Gilbert J. Fournié2,3,*,
  35. Ingrid Kockum1,*,
  36. Abdelhadi Saoudi2,3,* and
  37. Tomas Olsson1,*
  1. 1Department of Clinical Neuroscience, Neuroimmunology Unit, Karolinska Institutet, S-17176 Stockholm, Sweden.
  2. 2Institut National de la Santé et de la Recherche Médicale, U563, F-31000 Toulouse, France.
  3. 3Université Toulouse III Paul Sabatier, F-31000 Toulouse, France.
  4. 4Department of Clinical Neuroscience, Division of Neurology, Karolinska Institutet, S-17186 Stockholm, Sweden.
  5. 5Danish Multiple Sclerosis Research Center, University of Copenhagen and Rigshospitalet, DK-2100 Copenhagen, Denmark.
  6. 6Department of Molecular Medicine, Institute of Molecular Medicine Finland, National Public Health Institute, FIN-00290 Helsinki, Finland.
  7. 7Department of Neurology, Helsinki University Central Hospital and Molecular Neurology Programme, Biomedicum, University of Helsinki, FIN-00290 Helsinki, Finland.
  8. 8Department of Neurology, Oslo University Hospital Ullevål and University of Oslo, N-0407 Oslo, Norway.
  9. 9Department of Anatomy, Institute of Basal Medical Science, University of Oslo, N-0317 Oslo, Norway.
  10. 10Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, OX3 7BN Oxford, UK.
  11. 11Department of Medical Genetics and Faculty of Medicine, Division of Neurology, University of British Columbia, V6T 2B5 Vancouver, British Columbia, Canada.
  12. 12Department of Medicine, Rheumatology Unit, Karolinska Institutet, S-17176 Stockholm, Sweden.
  13. 13Institute of Environmental Medicine, Karolinska Institutet, S-17177 Stockholm, Sweden.
  14. 14Hôpital Purpan, Service de Neurologie, F-31300 Toulouse, France.
  15. 15CHRU de Pontchaillou, Service de Neurologie, F-35033 Rennes Cedex 09, France.
  16. 16Institut National de la Santé et de la Recherche Médicale, UMR 975, F-75013 Paris, France.
  17. 17Université Pierre et Marie Curie-Paris 6, F-75013 Paris, France.
  18. 18Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France.
  1. To whom correspondence should be addressed. E-mail: tomas.olsson{at}ki.se

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