Contents
Vol 1, Issue 10
Contents
Commentary
- Traversing the Valley of Death: A Guide to Assessing Prospects for Translational Success
In an attempt to help investigators judge the likelihood that a translational project will be successful, we propose a series of questions that form a self-guided global risk assessment tool.
Perspective
- Parallel Paths to Predictive Biomarkers in Oncology: Uncoupling of Emergent Biomarker Development and Phase III Trial Execution
Predictive biomarkers can be integrated into phase III clinical trials by several approaches, including one that anticipates that a new biomarker will emerge during the course of the trial.
Research Article
- A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
VAV1 plays a role in regulating proinflammatory cytokines, which underlie the susceptibility for developing experimental autoimmune encephalomyelitis and multiple sclerosis.
Editors' Choice
- A Better Bionic Heart
Patients with a new type of heart pump that has a rotor to drive blood flow instead of a piston survive better because they have fewer complications.
- Grow Your Own Stem Cells
Induced pluripotent stem cells grown on their own parent fibroblasts are stable and lack common culture-related problems, paving the way for production of clinical-grade iPS cells.
- Lipid Liaison
A lipid chaperone in macrophages links ER stress with atherosclerosis.
- Measuring Metastatic Melanoma's Risk
Patients with melanomas that express more immune-related genes and show less cell division have a better chance of survival.
Erratum