Contents

Contents

• Commentary

  • Traversing the Valley of Death: A Guide to Assessing Prospects for Translational Success

    By Barry S. Coller, Robert M. Califf

    Science Translational Medicine09 Dec 2009 : 10cm9 Full AccessRestricted Access

    In an attempt to help investigators judge the likelihood that a translational project will be successful, we propose a series of questions that form a self-guided global risk assessment tool.

    • Abstract
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• Perspective

  • Parallel Paths to Predictive Biomarkers in Oncology: Uncoupling of Emergent Biomarker Development and Phase III Trial Execution

    By Robert Sikorski, Bin Yao

    Science Translational Medicine09 Dec 2009 : 10ps11 Full AccessRestricted Access

    Predictive biomarkers can be integrated into phase III clinical trials by several approaches, including one that anticipates that a new biomarker will emerge during the course of the trial.

    • Abstract
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• Research Article

  • A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

    By Maja Jagodic, Celine Colacios, Rita Nohra, Anne S. Dejean, Amennai Daniel Beyeen, Mohsen Khademi, Audrey Casemayou, Lucille Lamouroux, Christine Duthoit, Olivier Papapietro, Louise Sjöholm, Isabelle Bernard, Dominique Lagrange, Ingrid Dahlman, Frida Lundmark, Annette B. Oturai, Helle B. Soendergaard, Anu Kemppinen, Janna Saarela, Pentti J. Tienari, Hanne F. Harbo, Anne Spurkland, Sreeram V. Ramagopalan, Dessa A. Sadovnick, George C. Ebers, Maria Seddighzadeh, Lars Klareskog, Lars Alfredsson, Leonid Padyukov, Jan Hillert, Michel Clanet, Gilles Edan, Bertrand Fontaine, Gilbert J. Fournié, Ingrid Kockum, Abdelhadi Saoudi, Tomas Olsson

    Science Translational Medicine09 Dec 2009 : 10ra21 Full AccessRestricted Access

    VAV1 plays a role in regulating proinflammatory cytokines, which underlie the susceptibility for developing experimental autoimmune encephalomyelitis and multiple sclerosis.

    • Editor's Summary
    • Abstract
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• Editors' Choice

  • A Better Bionic Heart

    By Katrina L. Kelner

    Science Translational Medicine09 Dec 2009 : 10ec35 Full AccessRestricted Access

    Patients with a new type of heart pump that has a rotor to drive blood flow instead of a piston survive better because they have fewer complications.

    • Summary
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  • Grow Your Own Stem Cells

    By Kelly LaMarco

    Science Translational Medicine09 Dec 2009 : 10ec36 Full AccessRestricted Access

    Induced pluripotent stem cells grown on their own parent fibroblasts are stable and lack common culture-related problems, paving the way for production of clinical-grade iPS cells.

    • Summary
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  • Lipid Liaison

    By Lily Khidr

    Science Translational Medicine09 Dec 2009 : 10ec37 Full AccessRestricted Access

    A lipid chaperone in macrophages links ER stress with atherosclerosis.

    • Summary
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  • Measuring Metastatic Melanoma's Risk

    By Heather B. McDonald

    Science Translational Medicine09 Dec 2009 : 10ec38 Full AccessRestricted Access

    Patients with melanomas that express more immune-related genes and show less cell division have a better chance of survival.

    • Summary
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• Erratum

  • Correction to the Research Article Titled “Serum Amyloid P Inhibits Fibrosis Through FcγR-Dependent Monocyte-Macrophage Regulation in Vivo” by A. P. Castaño et al.

    Science Translational Medicine09 Dec 2009 : 10er1 Full AccessRestricted Access

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