Contents
25 March 2020
Vol 12, Issue 536
Vol 12, Issue 536
Research Articles
- Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells
Papillary renal cell carcinoma derives from renal progenitors in an adenoma-carcinoma sequence, and acute kidney injury is a preventable risk factor.
- An ocular glymphatic clearance system removes β-amyloid from the rodent eye
Glymphatic pathway clears retinal β-amyloid in rodents via optic nerve and is impaired in glaucoma.
- Noninvasive localization of cardiac arrhythmias using electromechanical wave imaging
Electromechanical wave imaging accurately localizes atrial and ventricular cardiac arrhythmias in adult patients in a double-blinded clinical study.
- A high-salt diet compromises antibacterial neutrophil responses through hormonal perturbation
A high-salt diet in mice and humans impairs neutrophil antibacterial functions by dysregulating immunosuppressive steroid hormones.
- Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy
Genome-wide CRISPR-Cas9 screens identify druggable pathways associated with facioscapulohumeral muscular dystrophy.
- Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape
Inhibiting a specific isoform of TGFβ augments the effectiveness of checkpoint blockade therapy in cancer treatment.
Editors' Choice
- Quarterly picks from the editors
The Science Translational Medicine editors highlight interesting translational ties across select articles published recently in the Science family of journals.
- Out of the frying pan into the fire: IFN-γ in post-sepsis immunosuppression
Secretion of IFN-γ in sepsis contributes to post-sepsis immunosuppression and secondary candidemia.
- Beyond synuclein: Organelle accumulation in Lewy bodies may drive neurodegeneration
Organelle sequestration in Lewy bodies correlates more closely with neurodegeneration than α-synuclein aggregation alone.
- Wireless monitoring in the ICU
Monitoring of critically ill children can be improved by a soft, flexible wireless device that generates accurate, comprehensive, and continuous data.
About The Cover
ONLINE COVER Kidney Confetti. This image depicts a developing papillary renal carcinoma in the kidney of a Confetti mouse, in which individual tubular epithelial cells in the kidney are tagged with different fluorochromes. Collagen IV is labeled in cyan, and all other colors are nonspecific fluorochromes marking individual kidney cells. These fluorochromes allow tracking of kidney development and evolution of incipient tumors. Using these mouse models as well as multiple cohorts of human patients, Peired et al. demonstrated that acute kidney injury increases the risk of subsequent papillary renal cancer and identified an underlying mechanism. [CREDIT: PAOLA ROMAGNANI]
