Contents
04 December 2019
Vol 11, Issue 521
Vol 11, Issue 521
Research Articles
- Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction
Transient EEG slowing events are shared by patients and models of Alzheimer’s and epilepsy and are associated with blood-brain barrier dysfunction.
- Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction
Age-related breakdown of blood-brain barrier activates astrocytic TGFβ signaling to cause neural dysfunction and cognitive impairment.
- Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer
Cellular heterogeneity of PCa contributes to hormonal therapy failure, but CXCR2 on neuroendocrine cells is a potential therapeutic target.
- The human tissue-resident CCR5+ T cell compartment maintains protective and functional properties during inflammation
Human CD69+CCR5+ T cells in mucosal tissues are poised to maintain barrier immunity in healthy and inflamed tissues.
- In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model
The malaria parasite Plasmodium falciparum readily develops resistance to dihydroorotate dehydrogenase inhibitors in vitro and in a mouse model of infection.
Report
- A once-a-month oral contraceptive
An oral dosage form that resides in the stomach releases the contraceptive levonorgestrel over 1 month in pigs.
Editors' Choice
- Colitis from a chubby colon
Neonatal overfeeding causes disruptions in the microbiome and intestinal homeostasis, which precedes colitis development in adulthood.
- Probiotics leap from gut to blood
In critically ill patients, probiotics are associated with probiotic strain bacteremia and can evolve in response to antibiotic administration.
- One vector to rule them all
A combination of gene therapies improves age-associated diseases.
About The Cover
ONLINE COVER None Shall Pass. This illustration represents the blood-brain barrier (BBB), a tight-knit border of endothelial cells, pericytes, and astrocytes that separates the brain from the systemic circulation. Loss of BBB integrity contributes to neurological diseases, such as Alzheimer's disease (AD) and epilepsy and to cognitive impairment in aging. In this issue, a pair of studies investigated the effects of BBB dysfunction on neuronal networks and cognition. BBB impairments were spatially associated with electroencephalographic abnormalities in patients with AD or epilepsy and in aging mice (Milikovsky et al.). In aging rodents, cognitive impairments mediated by activation of TGFβ triggered by BBB leakage were restored by inhibiting TGFβ (Senatorov et al.). These studies highlight the importance of proper BBB function for maintaining neuronal homeostasis. [CREDIT: GUNILLA ELAM/SCIENCE SOURCE]
