Contents
12 May 2021
Vol 13, Issue 593
Vol 13, Issue 593
Research Articles
- CD4+ T cells are essential for the development of destructive thyroiditis induced by anti–PD-1 antibody in thyroglobulin-immunized mice
CD4+ T cells are essential for development of thyroiditis induced by anti–PD-1 antibody treatment in thyroglobulin-immunized mice.
- The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates
LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection.
- Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease
Semorinemab shows beneficial effects in preclinical models and engages tau in a phase 1 study of patients with Alzheimer’s disease.
- Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide
Avasopasem manganese enhances tumor cell killing after ablative hypofractionated radiation through the generation of hydrogen peroxide.
- An oral antisense oligonucleotide for PCSK9 inhibition
A highly potent, chemically modified PCSK9 antisense oligonucleotide formulated with a permeation enhancer was developed for oral administration.
Report
- A portable magnetofluidic platform for detecting sexually transmitted infections and antimicrobial susceptibility
A portable magnetofluidic platform integrates nucleic acid purification and PCR to rapidly detect the pathogen causing gonorrhea in clinical samples.
Technical Comment
- Comment on “Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI”
The nuclear pregnane X receptor may not protect against ischemia/reperfusion-induced acute kidney injury in mice.
Technical Response
- Response to comment on “Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI”
The nuclear pregnane X receptor protects against bilateral renal ischemia/reperfusion-induced acute kidney injury in mice.
About The Cover
ONLINE COVER Destructive CD4+ T Cells. This image shows a hematoxylin and eosin-stained section of an inflamed mouse thyroid following immunization with thyroglobulin and treatment with programmed cell death protein 1 (PD-1) antibody. Immune-related adverse events (irAEs) sometimes occur in patients treated with PD-1 antibody or other immune checkpoint blockade therapies. One type of irAE is destructive thyroiditis, where immune cells kill healthy thyroid cells. In this study, Yasuda et al. developed a mouse model of destructive thyroiditis and showed that a population of cytotoxic CD4+ T cells are essential for thyroid damage. These findings suggest that CD4+ T cells should be investigated as mediators of irAEs in humans treated with PD-1 antibody. [CREDIT: YASUDA ET AL./SCIENCE TRANSLATIONAL MEDICINE]
