Contents
17 April 2019
Vol 11, Issue 488
Vol 11, Issue 488
Research Articles
- In utero gene editing for monogenic lung disease
Prenatal CRISPR gene editing results in efficient pulmonary epithelial cell editing and ameliorates a mouse model of a congenital lung disease.
- Temperature-responsive biometamaterials for gastrointestinal applications
Temperature-responsive, reconfigurable metamaterials actuated by ingestion of warm water can be applied to the upper gastrointestinal tract.
- Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
Entacapone improves metabolic homeostasis in diet-induced obese mice through a direct effect on an FTO-FOXO1 regulatory axis.
- Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer can be mediated by a reversible chemotherapy-tolerant state.
- Filamentous bacteriophages are associated with chronic Pseudomonas lung infections and antibiotic resistance in cystic fibrosis
Pseudomonas strains that produce filamentous bacteriophage are associated with chronic infection and increased antibiotic resistance in patients with cystic fibrosis.
Editors' Choice
- Synovial signatures signpost arthritis
Cellular signatures define pathobiological endotypes in early rheumatoid arthritis, informing prognosis and treatment.
- Targeting senescence within the Alzheimer’s plaque
Amyloid β drives senescence of oligodendrocyte progenitor cells, presenting a potential therapeutic target.
- An aspirin a day keeps metastasis at bay
Aspirin’s inhibition of COX-1/thromboxane A2 prevents metastasis by blocking adhesion between platelets, circulating tumor cells, and the endothelium.
About The Cover
ONLINE COVER Gene Editing to the Rescue. This conceptual image depicts a mouse fetus having its DNA sequence corrected to repair a pathogenic mutation. Alapati et al.. used CRISPR-Cas9, a method of targeted gene editing, to inactivate a mutant version of Sftpc, a gene that causes a lethal congenital lung disease, in mice. Because the lung disease is lethal at the time of birth, the researchers performed gene editing in utero. Editing improved the survival of mouse pups without causing adverse effects in their mothers. [CREDIT: EO TRUEBLOOD/THE CHILDREN'S HOSPITAL OF PHILADELPHIA]