Contents
16 October 2019
Vol 11, Issue 514
Vol 11, Issue 514
Research Articles
- Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation
A human neuropeptide S receptor mutation renders mutant mice to be short sleepers with more resilience to memory deficits caused by sleep deprivation.
- A modulator of wild-type glucocerebrosidase improves pathogenic phenotypes in dopaminergic neuronal models of Parkinson’s disease
New small-molecule modulators of wild-type glucocerebrosidase improve pathogenic phenotypes in different cellular models of Parkinson’s disease.
- Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants
Engineered conformability in auditory brainstem implant electrode arrays improves the electrode-brainstem interface in mice and in human cadavers.
- Astrocyte molecular signatures in Huntington’s disease
Astrocyte gene expression is altered in mouse models of Huntington’s disease and in postmortem brain samples from patients with HD.
- Cognitive refractory state caused by spontaneous epileptic high-frequency oscillations in the human brain
Epileptic brain tissue functions normally outside the ~1.3-s window preceding pathological activity.
Editors' Choice
- Keeping nanoparticles within the joint
Manganese dioxide nanoparticles target chondrocytes, protecting cartilage tissue from inflammation-induced oxidative damage.
- A real-life cyborg brain
A wireless brain neural interface and four-limp exoskeleton enabled a tetraplegic man to grasp and walk again.
- A new function for polycomb in immune evasion
Polycomb repressive complex 2 silences MHC class I gene expression.
About The Cover
ONLINE COVER Sampling Neuroscience. The cover depicts human brain specimens, highlighting this issue's focus on translational neuroscience to coincide with the Society for Neuroscience annual meeting. Five Research Articles showcase progress on several different fronts. Using intracranial electroencephalography in patients with epilepsy, Liu et al. report physiological oscillations in brain tissue in response to cognitive stimuli. Meanwhile, Xing et al. established neuropeptide S as a mediator of sleep-induced memory consolidation in mice. Tackling neurodegenerative disorders, Diaz-Castro et al. identified an astrocyte gene signature in Huntington's disease, and Burbulla et al. treated Parkinson's disease cellular models with a small-molecule modulator of wild-type β-glucocerebrosidase. Finally, Vachicouras et al. report development of a soft auditory brainstem implant that conforms to the curvature of the cochlear nucleus for treating hearing loss. [CREDIT: GUY GILLETTE/SCIENCE SOURCE]
