Contents
22 May 2019
Vol 11, Issue 493
Vol 11, Issue 493
Review
- Mouse models of neurodegeneration: Know your question, know your mouse
There are many mouse models for studying neurodegeneration, but it is crucial to select the model that best fits the research question being asked.
Research Articles
- Primary cilia defects causing mitral valve prolapse
Genetic variations in primary cilia genes cause defects during valve morphogenesis that can progress to mitral valve prolapse in the adult.
- Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation
Catheter ablation for atrial fibrillation induces intracardiac neural damage characterized by glial S100B release, which promotes nerve sprouting.
- Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection
Immediate initiation of antiviral therapy in acute HIV infection results in functional and persistent T cell responses.
- Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates
Lentiviral vectors with high surface content of CD47 improved gene transfer efficiency to hepatocytes in nonhuman primates.
- Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium
Liquid biopsy of circulating exosomes can be used to monitor recovery of ischemic myocardium after transplanting cardiac progenitor cells.
Editors' Choice
- Waving off neurodegeneration
Gamma wave oscillations provide neuroprotection in mouse models of Alzheimer’s disease.
- A sight for sore eyes (or ones with glaucoma)
Transduction of the exoenzyme C3 transferase gene into the trabecular meshwork reduces intraocular pressure in monkeys.
Erratum
About The Cover
ONLINE COVER Taking Cilia to Heart. This image depicts heart valve tissue from a newborn mouse, with cilia highlighted in green, nuclei in blue, and versican (a component of the extracellular matrix) in gray. By tracking the development of heart valves in mice and analyzing gene associations in human patients, Toomer et al. identified an association between cilia defects and mitral valve prolapse, a common congenital heart condition. [CREDIT: KATELYNN TOOMER AND RUSSELL NORRIS/MEDICAL UNIVERSITY OF SOUTH CAROLINA]