Contents
29 July 2020
Vol 12, Issue 554
Vol 12, Issue 554
Research Articles
- Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models of polycystic kidney disease.
- Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy
Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.
- Cellular senescence impairs the reversibility of pulmonary arterial hypertension
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
- The safety and clinical effects of administering a multiantigen-targeted T cell therapy to patients with multiple myeloma
Infusions of autologous T cells specific for multiple tumor antigens were safe and induced responses in some patients with multiple myeloma.
Report
- Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States
Analysis of influenza-like illness surveillance data estimates that most SARS-CoV-2 infections in the United States went undetected in March 2020.
Perspective
- Scientific considerations for global drug development
Scientific and technological advances could reduce the need for in-country or in-region confirmatory clinical trials.
Editors' Choice
- Stimulated bone growth and metal-infused skeletons: From comic books to commonplace
Three-dimensional titanium surfaces patterned with nanometer-sized features demonstrate accelerated bone growth and mineralization in mice.
- Living swine to maintain donor organs
Use of xenogeneic cross-circulation recovered injured human lungs and expand the pool of donor organs in lung transplantation.
- Understanding sex-related differences in immune responses
Sex hormone–related changes in neutrophil responsiveness to interferons may underlie differences in immune responses.
About The Cover
ONLINE COVER Protecting Kidneys from Cystic Disease. This computed tomography scan shows the kidneys of a patient with autosomal dominant polycystic kidney disease, a genetic disorder associated with the continued development of renal cysts and progressively worsening kidney function. In this image, most of one kidney has been replaced by cysts (red). Lu et al. discovered that inactivation of the antioxidant protein NRF2 plays a key role in the pathogenesis of this disease. The authors identified pharmacological interventions that activated the NRF2 pathway and slowed the progression of autosomal dominant polycystic kidney disease in mouse models. [CREDIT: ZEPHYR/SCIENCE SOURCE]
