Contents
04 August 2021
Vol 13, Issue 605
Vol 13, Issue 605
Focus
- Identifying and targeting the Achilles heel of a recalcitrant cancer
Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy’s antitumor response.
Research Articles
- Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia
Neuromuscular junction remodeling and deterioration due to impaired BMP signaling are associated with cancer-induced muscle wasting.
- TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
TGFβ2 and TGFβ3 isoforms are activated via unique mechanisms and are associated with fibrosis in human diseases.
- Formyl peptide receptor 1 signaling potentiates inflammatory brain injury
Formyl peptide receptor 1 facilitates brain inflammation and can be targeted to attenuate acute neural injury.
- Unfolded protein response inhibitors cure group A streptococcal necrotizing fasciitis by modulating host asparagine
Inhibiting the formation and release of host asparagine cures invasive group A streptococcal infections in mice.
- A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
A multiplexed virus-free surrogate neutralization assay measures antibody responses against spike protein mutations in SARS-CoV-2 variants.
- Dual targeting of CTLA-4 and CD47 on Treg cells promotes immunity against solid tumors
Selective CD47 blockade on CTLA-4high tumor-infiltrating Treg cells reduces systemic toxicity and enhances antitumor immunity.
About The Cover
ONLINE COVER Boosting Antitumor Immunity. The cover image shows a tumor from a patient with small cell lung cancer (SCLC) visualized with multiplexed ion beam imaging by time of flight. The image reveals the tumor-immune microenvironment, with tumor and immune cell populations expressing different markers including NEUROD1, a SCLC marker (red); CD14, a myeloid cell marker (green); and a marker of CD8+ T cells (magenta). This issue of Science Translational Medicine features a Focus article by Triparna Sen, the winner of the 2021 AAAS Martin and Rose Wachtel Cancer Research Award, which is given each year to a young scientist who has made important contributions to the field of cancer research. [CREDIT: Y. XIE, Y. LI, AND T. J. HOLLMANN/MSKCC]
