Contents
05 May 2021
Vol 13, Issue 592
Vol 13, Issue 592
Research Articles
- Hexachromatic bioinspired camera for image-guided cancer surgery
A color/near-infrared camera inspired by the mantis shrimp visual system enables tumor detection and lymph node mapping during cancer surgery.
- A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells
Tumor cells using the ALT mechanism to maintain telomeres are uniquely sensitive to PARP inhibitor–induced lethal chromosomal fusion.
- Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease
In vivo IL-17A activity is elevated in active tuberculosis and may be a therapeutic target to attenuate disease-associated immunopathology.
- An RNA aptamer restores defective bone growth in FGFR3-related skeletal dysplasia in mice
We report reversal of the FGFR3-related skeletal dysplasia by RNA aptamer designed to neutralize FGFR3 ligand FGF2.
- iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension
Drug screening for improved function and transcriptomics of iPSC-derived endothelial cells from patients with pulmonary hypertension reveals AG1296.
- Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology.
- A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma
A highly cytotoxic T cell memory subset demonstrates intrinsic advantages when used as a CAR T cell platform in a solid tumor model.
About The Cover
ONLINE COVER Engineering Inspired by a Marine Crustacean. The compound eyes of the mantis shrimp (pictured) are a marvel of biological engineering, with 16 types of cone cells positioned on two eyestalks providing highly efficient visual information unmatched by any man-made spectral camera. Using the mantis shrimp eyes as their guide, Blair et al. designed a camera with vertically stacked silicon photodetectors and spectral filters positioned on a single chip that detected multiple colors and near-infrared light. This hexachromatic camera distinguished healthy tissue from cancerous tissue in tumor-bearing mice and enabled surgeons to map lymph nodes close to tumors in patients with breast cancer undergoing surgical resection. This bioinspired camera may have a bright future in image-guided cancer surgery. [CREDIT: GEORGETTE DOUWMA/MINDEN]
