Contents
28 July 2021
Vol 13, Issue 604
Vol 13, Issue 604
Research Articles
- An ACE inhibitor reduces bactericidal activity of human neutrophils in vitro and impairs mouse neutrophil activity in vivo
ACE inhibitor treatment reduces human and mouse neutrophil function.
- Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy
Disruption of the molecular interaction between CD93 and IGFBP7 improves tumor vascular functions and thereby facilitates therapeutic interventions.
- Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion
Survival of neutrophils is prolonged, and their function is preserved by simultaneously targeting multiple cell death pathways.
- Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs.
- PARIS farnesylation prevents neurodegeneration in models of Parkinson’s disease
Farnesol enhances the amounts of farnesylated PARIS and PGC-1α, preventing dopaminergic neuronal loss in Parkinson’s disease models.
- Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
Depletion of Chop in pancreatic β cells optimizes insulin secretion and reduces fatty liver in preclinical models.
About The Cover
ONLINE COVER An ACE Up Neutrophils' Sleeves. This Gram-stained image shows vegetative growth of methicillin-resistant Staphylococcus aureus (MRSA, purple) in the heart of a catheterized angiotensin-converting enzyme (ACE)–deficient mouse after intravenous MRSA challenge. Millions of people are prescribed ACE inhibitors (ACEIs) to control blood pressure. Here, Cao et al. aimed to investigate the impact of ACEI treatment on susceptibility to infection. They found that treatment of mice or human volunteers with ACEIs reduced bactericidal activity of isolated neutrophils in vitro. ACE deficiency or ACEI treatment also increased bacterial infection severity in mice in vivo. Together, these data suggest that alternatives to ACEIs may need to be considered for those at increased risk of bacterial infection. [CREDIT: CAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]
