Contents
21 April 2021
Vol 13, Issue 590
Vol 13, Issue 590
Research Articles
- The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia
Pharmacological manipulation of the melanocortin-3 receptor bidirectionally controls feeding, providing a therapeutic target for eating disorders.
- Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents
Administration of extracellular vesicles derived from amniotic fluid stem cells regenerates underdeveloped fetal lungs in rodents.
Report
- SARS-CoV-2 infection of human iPSC–derived cardiac cells reflects cytopathic features in hearts of patients with COVID-19
Infection of human iPSC–derived cardiomyocytes by SARS-CoV-2 leads to specific cytopathic features reflected in patient autopsy samples.
Research Articles
- T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals
Longitudinal analysis identifies SARS-CoV-2 peptide targets of durable memory T cell responses in COVID-19 convalescent individuals.
- Patient-derived glial enriched progenitors repair functional deficits due to white matter stroke and vascular dementia in rodents
A specific prorepair glial stem cell therapy promotes brain repair in vascular dementia in rodent models.
- Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial
Neutralization of endothelial lipase with a monoclonal antibody raises functional HDL in both nonhuman primates and in healthy humans.
About The Cover
ONLINE COVER Axons in Anorexia. The image shows Mc3r mRNA (green) in Agrp (red)- and Pomc (blue)-expressing AgRP (Agouti-related protein) neurons in the arcuate nucleus of the mouse hypothalamus. Sweeney et al. showed that AgRP neurons, known to regulate feeding behavior, can be bidirectionally controlled by deletion of Mc3r or pharmacological manipulation of melanocortin-3 receptor (MC3R). MC3R-specific agonists increased feeding in male and female mice, including models of anorexia, by modulating AgRP neurons. Conversely, inhibition of MC3R suppressed food intake. These results suggest that MC3R may constitute a therapeutic target for anorexia nervosa. [CREDIT: SWEENEY ET AL./SCIENCE TRANSLATIONAL MEDICINE]
