Contents
03 June 2020
Vol 12, Issue 546
Vol 12, Issue 546
Perspective
- COVID-19 diagnostics in context
Understanding the performance of existing COVID-19 tests and different clinical needs can inform development of next-generation tests.
Research Articles
- In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness
Base editing in postnatal mice repairs a recessive hearing loss mutation, rescues sensory transduction, and transiently restores auditory function.
- Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia
Dissecting the immune architecture of AML and its influence on therapeutic response identifies patients for whom immunotherapy will be most beneficial.
- Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function
Gene editing to insert a strong promoter upstream of endogenous FOXP3 conferred Treg-like properties and functions to primary human CD4+ T cells.
- Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis
Autophagy-driven nuclear transfer of miR-126-5p guided by Mex3a enables direct inhibition of caspase-3 and protects against atherosclerosis.
- An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells
A peptide from the HIV envelope protein inactivates HIV-1 virions in vitro and suppresses the viral load of chronically SHIV-infected macaques.
Editors' Choice
- Following the rules to foil Gram-negative infections
Molecular design principles increase accumulation of an antibiotic in multidrug resistant Gram-negative bacteria.
- Platelets worsen tuberculosis disease progression: Specific mechanism TBD
Platelets contribute to the progression of tuberculosis by impairing the oxidative burst of alveolar macrophages via an unknown mechanism.
- Coexpression of αβ and γδ TCRs bridges innate and adaptive immunity
T cells coexpressing αβ and γδ TCRs demonstrate characteristics of both αβ and γδ T cells, providing a link between innate and adaptive immune responses.
Erratum
About The Cover
ONLINE COVER Benefits of Base Editing. This image shows the basal portion of the mouse cochlea, part of the inner ear involved in hearing. Recessive point mutations in the transmembrane channel-like 1 (TMC1) gene cause abnormal hair cell morphology and hearing loss. Yeh et al. developed a mouse model of recessive hearing loss due to a point mutation in Tmc1. In vivo base gene editing in newborn mice partially corrected the mutation, improving sensory hair cell morphology and transiently rescuing auditory function. The results suggest that base editing might be effective for treating recessive forms of hearing loss. [CREDIT: YEH ET AL./SCIENCE TRANSLATIONAL MEDICINE]
