Contents
17 July 2019
Vol 11, Issue 501
Vol 11, Issue 501
Focus
- Diverse compositions and functions of chromatin remodeling machines in cancer
Human cancer genetics power biochemical and functional interrogation of chromatin remodeling complexes, informing therapeutic opportunities.
Research Articles
- Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis
Inhibition of calpain 9, a key mediator of myofibroblast differentiation and tissue fibrosis, protects against fibrosis in preclinical models.
- A multimodality test to guide the management of patients with a pancreatic cyst
Molecular and clinical markers outperform current clinical and imaging criteria for the diagnosis and management of patients with pancreatic cysts.
- Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment
A STAT1-driven inflammatory phenotype associated with response to checkpoint blocking antibodies sensitizes cancers to immunotherapy.
- Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity
Live-attenuated, spread-deficient rhesus CMV vectors retain T cell immunogenicity.
- A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge
Highly attenuated pp71-deleted RhCMV/SIV vectors elicit immune responses that stringently protect 59% of vaccinated monkeys from SIV challenge.
Technical Comment
- Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL human leukemia”
LB100 does not sensitize CML stem cells to tyrosine kinase inhibitor–induced apoptosis.
Technical Response
- Response to Comment on “PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia”
LB100 sensitizes resistant chronic phase CML stem and progenitor cells to TKIs and spares healthy bone marrow cells.
Editors' Choice
- Innate lymphoid cells pack on the pounds
Small intestine innate lymphoid cells induce diet-related obesity in mouse models.
- A mitochondrial Pac-man drug to tackle aging
Urolithin A, an activator of mitophagy, is safe to use and increases skeletal muscle mitochondrial gene expression in elderly individuals.
- A probiotic for treating cancer
A probiotic engineered to express a fusion of two tumor-inhibiting proteins shows targeted anticancer activity in mice.
About The Cover
ONLINE COVER SNF-ing Out Mechanisms of Oncogenesis. This image depicts the mammalian SWI/SNF (switch/sucrose non-fermentable) chromatin remodeling complex, illustrating the work of Cigall Kadoch, the winner of this year's AAAS Martin and Rose Wachtel Cancer Research Award. Dr. Kadoch studies the role of chromatin remodeling in cancer to identify potential therapeutic opportunities. The winner discusses her work in a Focus article and will also present a lecture based on her research on Friday, 19 July 2019, at the National Institutes of Health. [CREDIT: DAVID BOLINSKY]
