Contents
14 April 2021
Vol 13, Issue 589
Vol 13, Issue 589
Research Articles
- Brain injury instructs bone marrow cellular lineage destination to reduce neuroinflammation
Intracerebral hemorrhage skews bone marrow hematopoietic stem cells toward myeloid cell lineages that reduce neuroinflammation and brain injury.
- Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography
18F-FDS PET/CT can detect and localize infections due to Enterobacterales in patients and noninvasively monitor response to antibiotic treatment.
- Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia
Rituximab-resistant memory B cells and newly engaged naive B cells join to fuel subsequent autoimmune responses in patients with relapsing ITP.
- Triple-modality therapy maximizes antitumor immune responses in a mouse model of mesothelioma
Combining IL-15 superagonist and anti-GITR agonist therapy enhances antitumor effects of radiation therapy in a mouse model of mesothelioma.
- Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settings
Simple group testing designs to improve SARS-CoV-2 surveillance in resource-constrained settings are identified using modeling and experimental data.
Report
- Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT-PCR tests
Adaptive sample pooling for SARS-CoV-2 testing based on positivity rates spares 76% of test reactions without compromising specificity or sensitivity.
About The Cover
ONLINE COVER Adrenergic Guidance. The image shows a computer-enhanced scan of a human brain with an intracerebral hemorrhage (ICH, red area). After ICH, there is an increase in circulating monocytes that subsequently enter the brain parenchyma and modulate neuroinflammation. Shi et al. investigated the mechanisms mediating the impact of ICH on hematopoiesis and showed that activation of the adrenergic system by ICH triggered the production of Ly6Clow patrolling monocytes that entered the brain and reduced inflammation. These results may help the development of protective therapies to reduce brain inflammation after ICH. [CREDIT: SCOTT CAMAZINE/SCIENCE SOURCE]
