28 July 2021
Vol 13, Issue 604

About The Cover

Cover image expansion

ONLINE COVER An ACE Up Neutrophils' Sleeves. This Gram-stained image shows vegetative growth of methicillin-resistant Staphylococcus aureus (MRSA, purple) in the heart of a catheterized angiotensin-converting enzyme (ACE)–deficient mouse after intravenous MRSA challenge. Millions of people are prescribed ACE inhibitors (ACEIs) to control blood pressure. Here, Cao et al. aimed to investigate the impact of ACEI treatment on susceptibility to infection. They found that treatment of mice or human volunteers with ACEIs reduced bactericidal activity of isolated neutrophils in vitro. ACE deficiency or ACEI treatment also increased bacterial infection severity in mice in vivo. Together, these data suggest that alternatives to ACEIs may need to be considered for those at increased risk of bacterial infection. [CREDIT: CAO ET AL./SCIENCE TRANSLATIONAL MEDICINE]