Contents
15 January 2020
Vol 12, Issue 526
Vol 12, Issue 526
Research Articles
- Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance
Inhibition of stromal cell PKC-β mitigates environment-mediated drug resistance in B cell malignancies.
- Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology
Excessive cerebellar oscillations, resulting from GluRδ2-dependent pruning deficits of climbing fiber–to–Purkinje cell synapses, drive tremor.
- Intratumoral expression of IL-7 and IL-12 using an oncolytic virus increases systemic sensitivity to immune checkpoint blockade
Oncolytic vaccinia virus encoding IL-7 and IL-12 facilitates immune checkpoint blockade in treatment-resistant solid tumors.
- Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization
Human umbilical cord perivascular mesenchymal stromal cells improve vascularization and glycemic control of human islets implanted in mice.
- Engraftment of rare, pathogenic donor hematopoietic mutations in unrelated hematopoietic stem cell transplantation
Donor hematopoietic clones with pathogenic mutations engraft and persist in unrelated hematopoietic stem cell transplant recipients.
- β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
Noradrenergic signaling sensitizes pathological GSK3β/tau activation to nanomolar Aβ.
Editors' Choice
- Weighing in on asthma
Immune activation and microbiota alterations are accentuated in obese asthmatics.
- The “cancer flu shot”?
Direct injection of an influenza vaccine into tumors in mice increases immune infiltration and prolongs survival.
- Organoid optimization: Engineering a better cell therapy to treat type 1 diabetes
Islet organoids reaggregated in endothelialized collagen constructs improve engraftment and function in the subcutaneous space in diabetic mice.
About The Cover
ONLINE COVER Dismantling Tumors, Brick by Brick. In this image, the brown bricks depict a B cell tumor, resting on a base of green bricks representing the bone marrow microenvironment (stroma). The purple brick symbolizes PKC-β, a protein produced by the stroma that helps support the tumor cells and promotes their survival. Park et al. examined the tumorigenic role of PKC-β and demonstrated that PKC-β inhibitors, illustrated by the hand removing the purple brick, improved the cytotoxicity of chemotherapies in multiple leukemia models in vitro and in mice. [CREDIT: ELENA CALDERA]
