Table 3 Relationship of NREM SWA to AV-45 amyloid PET composite after adjusting for age, sex, race, CDR, ApoE4 status, AHI, PLMI, sleep medications, and time.

Linear mixed models were used to calculate the estimates and P values for the 38 participants with PET imaging.

Dependent variableCovariateEstimateSEF statistic (df)P
1–4.5 Hz SWAMean cortical AV-45
amyloid composite
−4.9262.4224.14 (1,28)0.052
Age−0.6800.2706.36 (1,28)0.018
Sex−8.5902.9488.49 (1,28)0.007
CDR−3.4893.4631.02 (1,29)0.322
Race−10.0035.5673.23 (1,27)0.083
ApoE4 status+2.9463.3270.78 (1,27)0.384
Sleep medications+3.1244.9630.40 (1,27)0.534
AHI+0.1230.1830.45 (1,28)0.507
PLMI+0.0840.0621.83 (1,28)0.187
Time−0.0030.1420.00 (1,145)0.982
1–2 Hz SWAMean cortical AV-45
amyloid composite
−12.0175.6764.48 (1,28)0.043
Age−1.5630.6326.12 (1,28)0.020
Sex−20.4016.9148.71 (1,28)0.006
CDR−10.1388.1391.55 (1,29)0.223
Race−23.32613.0413.20 (1,27)0.085
ApoE4 status+6.4277.7860.68 (1,27)0.416
Sleep medications−8.08611.6250.48 (1,27)0.493
AHI+0.2990.4310.48 (1,28)0.493
PLMI+0.1840.1461.59 (1,28)0.218
Time+0.0030.3550.00 (1,146)0.994
2–3 Hz SWAMean cortical AV-45
amyloid composite
−3.2391.8143.19 (1,28)0.085
Age−0.5140.2026.48 (1,28)0.017
Sex−6.0662.2057.57 (1,28)0.010
CDR−1.4722.5680.33 (1,28)0.571
Race−6.9364.1672.77 (1,28)0.107
ApoE4 status+2.1962.4980.77 (1,28)0.387
Sleep medications+1.6133.7160.19 (1,28)0.668
AHI0.0730.1370.29 (1,28)0.598
PLMI+0.0670.0462.09 (1,28)0.159
Time−0.0140.0950.02 (1,29)0.886
3–4 Hz SWAMean cortical AV-45
amyloid composite
−1.3500.6823.91 (1,28)0.058
Age−0.1830.0765.80 (1,28)0.023
Sex−2.2290.8307.21 (1,28)0.012
CDR−0.3390.9630.12 (1,27)0.727
Race−2.6451.5652.86 (1,27)0.102
ApoE4 status+0.6820.9390.53 (1,28)0.474
Sleep medications+0.4251.3960.09 (1,27)0.763
AHI+0.0240.0510.21 (1,28)0.647
PLMI+0.0240.0171.94 (1,28)0.175
Time−0.0030.0380.01 (1,27)0.928