Table 2 Relationship of NREM SWA to AV-1451 tau PET composite after adjusting for age, sex, race, CDR, ApoE4 status, AHI, PLMI, sleep medications, and time.

Linear mixed models were used to calculate the estimates and P values for the 38 participants with PET imaging. Time, longitudinal sleep monitoring.

Dependent variableCovariateEstimateSEF statistic
(df)
P
1–4.5 Hz SWAMean AV-1451 tau composite−8.8892.62511.46 (1,27)0.002
Age−0.6700.2437.59 (1,28)0.010
Sex−7.8502.6368.87 (1,28)0.006
CDR−6.8823.3124.32 (1,29)0.047
Race−9.2994.9503.53 (1,27)0.071
ApoE4 status+4.0022.8911.92 (1,27)0.178
Sleep medications+3.2254.4680.52 (1,27)0.476
AHI+0.1410.1660.73 (1,28)0.401
PLMI+0.1210.05375.09 (1,28)0.032
Time+0.00010.1420.00 (1,145)0.999
1–2 Hz SWAMean AV-1451 tau
composite
−21.4776.12312.30 (1,28)0.002
Age−1.5390.5677.36 (1,28)0.011
Sex−18.5426.1489.10 (1,28)0.005
CDR−18.3397.7505.60 (1,29)0.025
Race−21.62011.5373.51 (1,27)0.072
ApoE4 status+9.0446.7321.80 (1,27)0.190
Sleep medications+8.29810.4100.64 (1,27)0.432
AHI0.3460.3870.80 (1,28)0.379
PLMI0.2730.1254.76 (1,28)0.038
Time0.0130.3550.00 (1,146)0.970
2–3 Hz SWAMean AV-1451 tau
composite
−5.9191.9988.78 (1,28)0.006
Age−0.5090.1867.51 (1,28)0.011
Sex−5.5772.0097.71 (1,28)0.010
CDR−3.6542.5002.14 (1,28)0.155
Race−6.4963.7732.96 (1,28)0.096
ApoE4 status+2.9252.2101.75 (1,28)0.197
Sleep medications+1.7313.4100.26 (1,28)0.616
AHI+0.0850.1260.46 (1,28)0.504
PLMI+0.0920.0415.02 (1,28)0.033
Time−0.0130.0950.02 (1,29)0.891
3–4 Hz SWAMean AV-1451 tau
composite
−2.1860.7668.16 (1,27)0.008
Age−0.1810.0716.44 (1,28)0.017
Sex−2.0280.7726.90 (1,28)0.014
CDR−1.1500.9571.44 (1,27)0.240
Race−2.4061.4472.76 (1,27)0.108
ApoE4 status+1.0040.8491.40 (1,28)0.247
Sleep medications+0.4201.3080.10 (1,27)0.750
AHI+0.0270.0480.32 (1,28)0.577
PLMI+0.0350.0164.84 (1,28)0.036
Time−0.0040.0380.01 (1,28)0.914