Table 5 Relationship of NREM SWA to tau/Aβ42 ratio after adjusting for age, sex, race, CDR, ApoE4 status, AHI, PLMI, sleep medications, and time.

Linear mixed models were used to calculate the estimates and P values for the 104 participants with CSF.

Dependent variableCovariateEstimateSEF statistic
(df)
P
1–4.5 Hz SWATau/Aβ42−10.7884.6735.33 (1,12)0.040
Age+0.0340.1700.04 (1,12)0.846
Sex+0.8382.3500.13 (1,12)0.728
CDR+7.5672.8806.90 (1,14)0.020
Race−13.8603.81813.18 (1,9)0.006
ApoE4 status−6.9612.6456.92 (1,11)0.024
Sleep medications−19.6975.56512.53 (1,12)0.004
AHI+0.0560.1410.16 (1,11)0.699
PLMI+0.0600.0372.59 (1,13)0.132
Time−0.1540.1690.83 (1,70)0.365
1–2 Hz SWATau/Aβ42−25.75711.0785.41 (1,13)0.038
Age+0.1060.4030.07 (1,12)0.797
Sex+1.5715.5710.08 (1,12)0.783
CDR+16.4256.8075.82 (1,14)0.030
Race−31.1339.07411.77 (1,10)0.007
ApoE4 status−16.2166.2786.67 (1,12)0.025
Sleep medications−49.38613.19614.01 (1,13)0.003
AHI+0.1030.3330.10 (1,12)0.762
PLMI+0.1000.08751.31 (1,13)0.272
Time−0.4350.4061.15 (1,74)0.288
2–3 Hz SWATau/Aβ42−11.5943.25112.72 (1,11)0.004
Age+0.0080.1220.00 (1,12)0.952
Sex+0.3431.6800.04 (1,12)0.842
CDR+6.4311.76513.27 (1,8)0.006
Race−12.5672.73921.06 (1,9)0.001
ApoE4 status−5.9951.88910.07 (1,11)0.009
Sleep medications−19.9443.81027.40 (1,10)0.0004
AHI+0.0690.0970.50 (1,10)0.496
PLMI+0.0580.0255.28 (1,11)0.042
Time−0.0820.1290.41 (1,17)0.533
3–4 Hz SWATau/Aβ42−5.5491.68710.82 (1,10)0.008
Age−0.0190.0640.09 (1,11)0.773
Sex−0.0010.8780.00 (1,11)0.999
CDR+2.2230.9115.95 (1,10)0.036
Race−5.0761.40313.08 (1,8)0.006
ApoE4 status−2.1040.9784.63 (1,10)0.057
Sleep medications−6.7841.96511.92 (1,9)0.007
AHI+0.0400.0500.64 (1,10)0.444
PLMI+0.0290.0134.78 (1,10)0.053
Time−0.0190.0530.13 (1,15)0.719