Table 2. Effect of therapeutic vaccination on immunologic responses to HIV.

The frequency of study subjects whose CD3+CD4+ and CD3+CD8+ T cells responded to overlapping HIV peptides during the vaccination phase before treatment interruption. Changes in the frequency of cells expressing intracellular cytokines upon peptide stimulation over baseline were determined as described in Materials and Methods. PTEg, global potential T cell epitopes.

Peptide
pool
Number (percentage) of responders to HIV antigens
CD3+CD4+ T cellsCD3+CD8+ T cells
Vaccine
group
Placebo
group
Vaccine
group
Placebo
group
Env 1 PTEg4/12 (33%)0/13 (0%)5/13 (38%)3/13 (23%)
Env 2 PTEg4/13 (31%)0/13 (0%)2/13 (15%)0/13 (0%)
Gag 1 PTEg7/13 (54%)0/13 (0%)3/13 (23%)0/13 (0%)
Gag 2 PTEg5/13 (38%)2/13 (15%)1/13 (8%)0/13 (0%)
Nef PTEg0/13 (0%)1/13 (8%)1/13 (8%)0/13 (0%)
Pol 1 PTEg2/13 (15%)0/13 (0%)0/13 (0%)1/13 (8%)
Pol 2 PTEg3/13 (23%)1/13 (8%)0/13 (0%)1/13 (8%)