Table 1. Human tissue sample details and results obtained using the MasSpec Pen.

Pathological diagnosis, number of patient samples, and the Lasso prediction sensitivity, specificity, accuracy, and AUC obtained using a leave-one-out cross-validation approach are shown.

OrganPathologic evaluationNumber of patientsLasso prediction
DiagnosisHistologic typeSensitivitySpecificityAccuracyAUC
BreastNormal2987.5%100.0%95.6%1.00
CancerDuctal carcinoma16
Lung*Normal4797.9%95.7%96.8%0.97
CancerAdenocarcinoma1788.2%93.6%92.2%0.98
Squamous cell1788.2%95.7%93.8%0.93
Others14
OvaryNormal29100.0%89.7%94.7%0.98
CancerHigh-grade serous28
ThyroidNormal27
TumorPapillary carcinoma1894.4%100.0%97.8%0.99
Follicular adenoma1190.9%96.3%94.7%0.93

*Lasso prediction results for lung are shown for normal versus all cancer tissues (first row), followed by normal versus lung adenocarcinoma (middle row) and normal versus squamous cell carcinoma (last row).

†Lasso prediction results for thyroid are shown for normal versus malignant papillary carcinoma and normal versus benign follicular adenoma.