Table 1. Clinical findings on days 1 to 28 after EBOV challenge.

Hypothermia was defined as below 35°C. Fever was defined as >1.0°C higher than baseline. Mild rash was defined as focal areas of petechiae covering <10% of the skin, moderate rash as areas of petechiae covering 10 to 40% of the skin, and severe rash as areas of petechiae and/or ecchymosis covering >40% of the skin. Leukocytopenia and thrombocytopenia were defined as a >30% decrease in numbers of WBCs and platelets, respectively. Leukocytosis and thrombocytosis were defined as a twofold or greater increase in numbers of WBCs and platelets over baseline, where WBC count >11.000. ↑, two- to threefold increase; ↑↑, four- to fivefold increase; ↑↑↑, greater than fivefold increase; ↓, two- to threefold decrease; ↓↓, four- to fivefold decrease; ↓↓↓, greater than fivefold decrease. ALB, albumin; AMY, amylase; TBIL, total bilirubin; BUN, blood urea nitrogen; PHOS, phosphate; CRE, creatinine; GLU, glucose; GLOB, globulin; —, no change.

Animal IDTreatmentsFindingsStatus
Cyno72h
  A13 dpi Ad-IFN and
50 mg/kg mAb
Leukocytopenia (9 dpi), thrombocytopenia (6, 9 dpi)Survived
  A23 dpi Ad-IFN and
50 mg/kg mAb
Fever (22 dpi), leukocytopenia (6, 9, 25 dpi), leukocytosis (22 dpi),
thrombocytopenia (9, 16 dpi), thrombocytosis (3 dpi)
Died at 25 dpi
ALT↑ (3 dpi), ALP↑↑↑ (25 dpi), AMY↑ (3, 6, 16 dpi), BUN↓ (9 dpi),
CRE↓ (25 dpi), GLU↑↑↑ (25 dpi)
  A33 dpi Ad-IFN and
50 mg/kg mAb
Fever (22 dpi), leukocytopenia (9 dpi), leukocytosis (16, 22 dpi),
thrombocytopenia (6 dpi)
Survived
ALB↓ (16 dpi), ALT↑ (6, 9, 16 dpi)
  A43 dpi Ad-IFN and
50 mg/kg mAb
Leukocytosis (6, 16, 22 dpi), thrombocytopenia (3, 6, 8, 28 dpi)Survived
TBIL↑ (6, 8 dpi)
  B12 dpi mAb controlSevere rash (5 dpi), leukocytopenia (5 dpi), thrombocytopenia (5 dpi)Died at 5 dpi
TBIL↑ (5 dpi), BUN↑ (5 dpi), CRE↑↑ (5 dpi)
  B22 dpi PBS controlSevere rash (5 dpi), thrombocytopenia (5 dpi)Died at 5 dpi
ALP↑ (5 dpi), ALT↑↑↑ (5 dpi), BUN↑ (5 dpi), CRE↑↑ (5 dpi)
Cyno96h
  C11 dpi Ad-IFN and
4 dpi 50 mg/kg mAb
Fever (4 dpi), severe rash (6 dpi),
leukocytopenia (6 dpi), thrombocytopenia (4, 6 dpi)
Died at 6 dpi
ALT↑↑↑ (6 dpi), AMY↑↑↑ (6 dpi), TBIL↑↑ (6 dpi), BUN↑↑ (6 dpi),
PHOS↑↑↑ (6 dpi), CRE↑↑↑ (6 dpi), GLU↑↑↑ (6 dpi)
  C21 dpi Ad-IFN and
4 dpi 50 mg/kg mAb
Fever (21 dpi), mild rash (14 dpi), leukocytosis (10, 21, 28 dpi),
thrombocytopenia (7, 10, 14 dpi)
Survived
ALP↑ (14, 21, 28 dpi), GLU↑ (4, 7, 10 dpi)
  C31 dpi Ad-IFN and
4 dpi 50 mg/kg mAb
Hypothermia (14 dpi), leukocytopenia (7, 14 dpi), thrombocytopenia (4, 7, 10, 14, 21 dpi)Survived
CRE↑ (7 dpi)
  C41 dpi Ad-IFN and
4 dpi 50 mg/kg mAb
Hypothermia (10, 23 dpi), leukocytopenia (7, 14 dpi), leukocytosis (21 dpi),
thrombocytopenia (7, 10, 14 dpi)
Died at 23 dpi
BUN↑ (23 dpi), GLU↑ (23 dpi), GLOB↑ (21, 23 dpi)
  D11 dpi PBS and
4 dpi mAb control
Severe rash (6 dpi), leukocytopenia (6 dpi), thrombocytopenia (4, 6 dpi)Died at 6 dpi
ALP↑ (6 dpi), TBIL↑ (6 dpi), GLU↑ (6 dpi)
  D21 dpi PBS and
4 dpi PBS control
Severe rash (6 dpi), leukocytopenia (5 dpi), leukocytosis (2 dpi),
thrombocytopenia (4, 5 dpi)
Died at 5 dpi
ALB↓↓↓ (5 dpi), ALP↑↑↑ (5 dpi), ALT↑↑↑ (5 dpi), AMY↑↑ (5 dpi),
BUN↑↑ (5 dpi), PHOS↑↑↑ (5 dpi), CRE↑↑↑ (5 dpi), GLU↓ (5 dpi), GLOB↓↓↓ (5 dpi)
Rhesus72h
  E13 dpi Ad-IFN and
50 mg/kg mAb
Survived
  E23 dpi Ad-IFN and
50 mg/kg mAb
Thrombocytopenia (6 dpi)Survived
  E33 dpi Ad-IFN and 50
mg/kg mAb
Survived
  E43 dpi Ad-IFN and
50 mg/kg mAb
Leukocytosis (3, 9 dpi)Survived
  F13 dpi mAb controlModerate rash (6 dpi), leukocytopenia (7 dpi), thrombocytopenia
(6, 7 dpi), ALB↑ (7 dpi), ALT↑↑↑ (6, 7 dpi), TBIL↑ (6, 7 dpi), BUN↑ (6, 7 dpi),
PHOS↑↑ (7 dpi), CRE↑↑ (6 dpi) ↑↑↑ (7 dpi), GLU↓ (7 dpi), GLOB↑↑↑ (7 dpi)
Died at 7 dpi
  F23 dpi Ad-IFN only controlMild rash (6 dpi), moderate rash (9 dpi), leukocytosis (3 dpi),
thrombocytopenia (6, 9 dpi)
Died at 9 dpi
ALT↑↑ (6, 7 dpi), PHOS↓ (9 dpi)