Table 2 Clinical findings, days 0 to 28.

Thrombocytopenia was determined by Hemavet 950. Moderate petechial rash is defined as 10 to 40% of body surface area; severe petechial rash is defined as >40% of body surface area. AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; BUN, blood urea nitrogen; CRE, creatinine; GGT, γ-glutamyl transpeptidase; TBIL, total bilirubin; NS, nonsurvivor; S, survivor. ↑, two- to threefold increase; ↑↑, four- to fivefold increase; ↑↑↑, more than fivefold increase.

NHPTreatmentSymptoms presented/clinical findings
A (NS)MB-003Thrombocytopenia, AST ↑↑↑, BUN ↑, ALT ↑, CRE ↑, ALP, severe petechial rash, bleeding, dehydration, increasing
unresponsiveness, euthanized D9
B (NS)PBSThrombocytopenia, BUN ↑↑↑, CRE ↑↑↑, ALT ↑↑↑, AST ↑↑↑, ALP ↑↑, GGT ↑↑, severe petechial rash, dehydration,
increasing unresponsiveness, euthanized D7
C (S)MB-003Thrombocytopenia, ALT ↑↑, ALP ↑, GGT ↑
D (NS)MB-003Thrombocytopenia, severe petechial rash, bleeding, some unresponsiveness, found dead D12
E (S)MB-003Thrombocytopenia, ALP ↑, moderate petechial rash, unresponsiveness
F (NS)MB-003Thrombocytopenia, BUN ↑, CRE ↑, ALT ↑↑↑, AST ↑↑↑, ALP ↑, GLU ↓ moderate petechial rash, dehydration, increasing
unresponsiveness, euthanized D8
G (NS)Irrelevant mAbThrombocytopenia, BUN ↑↑, CRE ↑, ALT ↑↑↑, AST ↑↑↑, ALP ↑↑, GGT ↑↑, GLU ↓ moderate petechial rash, bleeding,
increasing unresponsiveness, loss of balance, euthanized D11
H (NS)MB-003Thrombocytopenia, BUN ↑↑↑, CRE ↑↑↑, ALT ↑↑↑, AST ↑↑↑, TBIL ↑, severe petechial rash, bleeding, dehydration,
increasing unresponsiveness, euthanized D10
I (S)MB-003Thrombocytopenia, ALP ↑, mild dehydration