Table 1 Activity of clomiphene and toremifene across native filovirus strains.

IC50, the concentration at which 50% inhibition of viral infection was observed; Max effect, the maximum percent inhibition observed.

EBOV/KikEBOV/MaySUDVMARVRAVV
CompoundIC50 (μM)Max effectIC50 (μM)Max effectIC50 (μM)Max effectIC50 (μM)Max effectIC50 (μM)Max effect
Clomiphene11.189.43.8397.84.9697.65.8297.07.1896.0
Toremifene1.7396.60.9733.833.9697.85.7395.76.1795.6