PT - JOURNAL ARTICLE AU - Lyden, Patrick AU - Lapchak, Paul TI - Sisyphus and Translational Stroke Research AID - 10.1126/scitranslmed.3005083 DP - 2012 Oct 17 TA - Science Translational Medicine PG - 156ps20--156ps20 VI - 4 IP - 156 4099 - http://stm.sciencemag.org/content/4/156/156ps20.short 4100 - http://stm.sciencemag.org/content/4/156/156ps20.full AB - After more than 1000 failures, we know that our methods for translating effective stroke treatments from the laboratory to the clinic do not work. New preclinical and clinical approaches conceived outside of the current paradigm exist and should be carefully considered. Now, Tymianski and colleagues report on results obtained during translation of a new neuroprotectant.