Supplementary Materials

Supplementary Material for:

Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection

Hiroshi Takata, Supranee Buranapraditkun, Cari Kessing, James L. K. Fletcher, Roshell Muir, Virginie Tardif, Pearline Cartwright, Claire Vandergeeten, Wendy Bakeman, Carmen N. Nichols, Suteeraporn Pinyakorn, Pokrath Hansasuta, Eugene Kroon, Thep Chalermchai, Robert O'Connell, Jerome Kim, Nittaya Phanuphak, Merlin L. Robb, Nelson L. Michael, Nicolas Chomont, Elias K. Haddad, Jintanat Ananworanich, Lydie Trautmann,* on behalf of the RV254/SEARCH010 and the RV304/SEARCH013 Study Groups

*Corresponding author. Email: ltrautmann{at}hivresearch.org

Published 15 February 2017, Sci. Transl. Med. 9, eaag1809 (2017)
DOI: 10.1126/scitranslmed.aag1809

This PDF file includes:

  • Materials and Methods
  • Fig. S1. HIV-specific CD8+ T cell expansion in AHI.
  • Fig. S2. CD4+ T cell activation in acute HIV-1 infection.
  • Fig. S3. Characteristics of effector CD8+ T cells and plasma viral load during different stages of AHI.
  • Fig. S4. Loss of memory potential and polyfunctionality of HIV-specific CD8+ T cell in AHI.
  • Fig. S5. Mitochondrial function of HIV-specific CD8+ T cell during different stages of AHI.
  • Fig. S6. HIV-specific CD8+ T cells 2 weeks after ART initiation during AHI.
  • Fig. S7. Association between HIV-specific CD8+ T cells and HIV reservoir after ART initiation during AHI.
  • Fig. S8. Association between activated CD4+ T cells and HIV reservoir after ART initiation during AHI.

[Download PDF]

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Primary data.