Supplementary Materials

Supplementary Material for:

Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates

Lucia Friedli, Ephron S. Rosenzweig, Quentin Barraud, Martin Schubert, Nadia Dominici, Lea Awai, Jessica L. Nielson, Pavel Musienko, Yvette Nout-Lomas, Hui Zhong, Sharon Zdunowski, Roland R. Roy, Sarah C. Strand, Rubia van den Brand, Leif A. Havton, Michael S. Beattie, Jacqueline C. Bresnahan, Erwan Bézard, Jocelyne Bloch, V. Reggie Edgerton, Adam R. Ferguson, Armin Curt, Mark H. Tuszynski, Grégoire Courtine*

*Corresponding author. E-mail: gregoire.courtine{at}epfl.ch

Published 26 August 2015, Sci. Transl. Med. 7, 302ra134 (2015)
DOI: 10.1126/scitranslmed.aac5811

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Clinical cases and experimental models of Brown-Séquard syndrome.
  • Fig. S2. Kinematics analysis uncovers similar patterns of locomotor deficits and compensation across species.
  • Fig. S3. Humans and monkeys, but not rats, recover hand kinematics and muscle activation patterns.
  • Fig. S4. Spinal cord decussating corticospinal fibers below the injury establishes synaptic contacts with neurons projecting to lumbar segments in monkeys.
  • Fig. S5. Increased density of corticospinal fibers above the hemisection in both rats and monkeys.
  • Fig. S6. Increased density of corticospinal tract fibers originating from the ipsilesional motor cortex fibers in segments below the hemisection in both rats and monkeys.
  • Fig. S7. Density of 5-hydroxytryptamine fibers below the hemisection remains unchanged in both monkeys and rats.
  • Fig. S8. The motor cortex fails to regain access to motoneurons below the hemisection in rats.
  • Table S1. Computed gait parameters.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Recovery of locomotion in monkeys and humans compared to rats after a lateral hemisection of the spinal cord.
  • Movie S2 (.mp4 format). Recovery of hand function in monkeys and humans compared to rats after a lateral hemisection of the spinal cord.