Research Article

The Predictive Capacity of Personal Genome Sequencing

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Science Translational Medicine  02 Apr 2012:
3003380
DOI: 10.1126/scitranslmed.3003380

Additional Files

  • Supplementary Material for:

    The Predictive Capacity of Personal Genome Sequencing

    Nicholas J. Roberts, Joshua T. Vogelstein, Giovanni Parmigiani, Kenneth W. Kinzler, Bert Vogelstein,* Victor E. Velculescu*

    *To whom correspondence should be addressed. E-mail: vogelbe{at}jhmi.edu (B.V.); velculescu{at}jhmi.edu (V.E.V.)

    Published 9 May 2012, Sci. Transl. Med. 4, 133ra58 (2012
    DOI: 10.1126/scitranslmed.3003380

    This PDF file includes:

    1. Fig. S1. Graphical representation of genometype frequency and risk distributions for (A) leukemia, (B) Alzheimer’s disease, and (C) pancreatic cancer.
    2. Table S1. Examples of known risk factors for common human diseases.
    3. Table S2. Thresholds and other parameters used to analyze each disease.
    4. Table S3. The risks and frequencies of each of the 20 genometypes providing maximum sensitivity (PF) for detection of each disease.
    5. Table S4. Percentage of cases (that is, individuals with disease) testing positive with whole-genome sequencing at varying risk thresholds or with the liability threshold (LT) model.
    6. Table S5. Percentage of population testing positive with whole-genome sequencing at varying risk thresholds.
    7. Table S6. Relative risk of disease if testing negative with whole-genome sequencing at varying risk thresholds.
    8. Table S7. Percentage of cases testing positive with whole-genome sequencing at varying estimates of nongenetic contributions.

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