- Supplementary Material for:
The Predictive Capacity of Personal Genome Sequencing
Nicholas J. Roberts, Joshua T. Vogelstein, Giovanni Parmigiani, Kenneth W. Kinzler, Bert Vogelstein,* Victor E. Velculescu*
*To whom correspondence should be addressed. E-mail:(B.V.); (V.E.V.)
Published 9 May 2012, Sci. Transl. Med. 4, 133ra58 (2012
This PDF file includes:
- Fig. S1. Graphical representation of genometype frequency and risk distributions for (A) leukemia, (B) Alzheimer’s disease, and (C) pancreatic cancer.
- Table S1. Examples of known risk factors for common human diseases.
- Table S2. Thresholds and other parameters used to analyze each disease.
- Table S3. The risks and frequencies of each of the 20 genometypes providing maximum sensitivity (PF) for detection of each disease.
- Table S4. Percentage of cases (that is, individuals with disease) testing positive with whole-genome sequencing at varying risk thresholds or with the liability threshold (LT) model.
- Table S5. Percentage of population testing positive with whole-genome sequencing at varying risk thresholds.
- Table S6. Relative risk of disease if testing negative with whole-genome sequencing at varying risk thresholds.
- Table S7. Percentage of cases testing positive with whole-genome sequencing at varying estimates of nongenetic contributions.