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Research Article
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
- Changhan Lee1,*,
- Lizzia Raffaghello2,*,
- Sebastian Brandhorst1,5,
- Fernando M. Safdie1,
- Giovanna Bianchi2 ,
- Alejandro Martin-Montalvo3,
- Vito Pistoia2,
- Min Wei1,
- Saewon Hwang1,
- Annalisa Merlino1,
- Laura Emionite4,
- Rafael de Cabo3 and
- Valter D. Longo1,†
- 1Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, CA 90089-0191, USA.
- 2Laboratory of Oncology, Giannina Gaslini Institute, Genova 16145, Italy.
- 3Laboratory of Experimental Gerontology. National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
- 4Animal Research Facility Istituto Tumori, Genova 16145, Italy.
- 5Centre for Medical Biotechnology, Faculty of Biology, University Duisburg–Essen, Essen, Germany
- ↵†To whom correspondence should be addressed. E-mail: vlongo{at}usc.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 08 Feb 2012:
3003293
DOI: 10.1126/scitranslmed.3003293
3003293
DOI: 10.1126/scitranslmed.3003293
Changhan Lee
Lizzia Raffaghello
Sebastian Brandhorst
Fernando M. Safdie
Giovanna Bianchi
Alejandro Martin-Montalvo
Vito Pistoia
Min Wei
Saewon Hwang
Annalisa Merlino
Laura Emionite
Rafael de Cabo
