Research ArticleBIOMATERIALS

A reversible thermoresponsive sealant for temporary closure of ocular trauma

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Science Translational Medicine  06 Dec 2017:
Vol. 9, Issue 419, eaan3879
DOI: 10.1126/scitranslmed.aan3879

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A sealant to save sight

Traumatic eye injuries require rapid treatment to prevent deterioration of vision. As an alternative to suturing or adhesives, Bayat and colleagues developed a temperature-responsive synthetic hydrogel that acts as a temporary sealant. Testing the hydrogel in a model of open globe injury in rabbits showed that the sealant was easily deployed from a custom-designed temperature-controlled syringe device and preserved intraocular pressure without evidence of chronic inflammation or toxicity. After gelation, the sealant could be removed by exposure to cold water. In combat or low-resource settings, this hydrogel could close wounds temporarily to prevent further tissue damage or vision loss before surgery.