Research ArticleMultiple Sclerosis

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

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Science Translational Medicine  06 Dec 2017:
Vol. 9, Issue 419, eaam7816
DOI: 10.1126/scitranslmed.aam7816

Article Information

vol. 9 no. 419

Print ISSN: 
Online ISSN: 
  • Received for publication January 16, 2017
  • Resubmitted July 13, 2017
  • Accepted for publication November 14, 2017

Author Information

  1. Maryam K. Fard1,*,,
  2. Franziska van der Meer2,*,
  3. Paula Sánchez1,
  4. Ludovico Cantuti-Castelvetri1,
  5. Sunit Mandad3,4,
  6. Sarah Jäkel5,
  7. Eugenio F. Fornasiero3,
  8. Sebastian Schmitt1,
  9. Marc Ehrlich6,7,
  10. Laura Starost6,7,
  11. Tanja Kuhlmann7,
  12. Christina Sergiou2,
  13. Verena Schultz2,
  14. Claudia Wrzos2,
  15. Wolfgang Brück2,
  16. Henning Urlaub4,8,
  17. Leda Dimou5,9,10,
  18. Christine Stadelmann2,, and
  19. Mikael Simons1,10,11,12,,
  1. 1Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.
  2. 2Department of Neuropathology, University of Göttingen Medical Center, 37075 Göttingen, Germany.
  3. 3Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, 37073 Göttingen, Germany.
  4. 4Max Planck Institute for Biophysical Chemistry, 37073 Göttingen, Germany.
  5. 5Department of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
  6. 6Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
  7. 7Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
  8. 8Bioanalytical Mass Spectrometry Group, Department of Clinical Chemistry, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Göttingen, Germany.
  9. 9Molecular and Translational Neuroscience, Department of Neurology, Medical Faculty, Ulm University, 89081 Ulm, Germany.
  10. 10Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
  11. 11Institute of Neuronal Cell Biology, Technical University of Munich, 80805 Munich, Germany.
  12. 12German Center for Neurodegenerative Diseases (DZNE), 6250 Munich, Germany.
  1. Corresponding author. Email: cstadelmann{at} (C.S.); khojasteh{at} (M.K.F.); msimons{at} (M.S.)
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work as co-senior authors.


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