Research ArticleHuntington’s Disease

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

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Science Translational Medicine  06 Dec 2017:
Vol. 9, Issue 419, eaal2332
DOI: 10.1126/scitranslmed.aal2332

Article Information

vol. 9 no. 419

PubMed: 
Print ISSN: 
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History: 
  • Received for publication October 18, 2016
  • Accepted for publication August 9, 2017

Author Information

  1. Audrey S. Dickey1,
  2. Dafne N. Sanchez1,
  3. Martin Arreola1,
  4. Kunal R. Sampat1,
  5. Weiwei Fan2,
  6. Nicolas Arbez3,
  7. Sergey Akimov3,
  8. Michael J. Van Kanegan4,
  9. Kohta Ohnishi1,
  10. Stephen K. Gilmore-Hall1,
  11. April L. Flores1,
  12. Janice M. Nguyen1,
  13. Nicole Lomas1,
  14. Cynthia L. Hsu1,
  15. Donald C. Lo4,
  16. Christopher A. Ross3,5,
  17. Eliezer Masliah6,7,
  18. Ronald M. Evans2,8 and
  19. Albert R. La Spada1,7,9,10,11,12,*
  1. 1Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
  2. 2Gene Expression Laboratory, Salk Institute for Biological Studies, San Diego, CA 92037, USA.
  3. 3Departments of Psychiatry, Neurology, and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  4. 4Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
  5. 5Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  6. 6Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
  7. 7Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
  8. 8Howard Hughes Medical Institute, Salk Institute for Biological Studies, San Diego, CA 92037, USA.
  9. 9Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  10. 10Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  11. 11Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  12. 12Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  1. *Corresponding author. Email: alaspada{at}ucsd.edu

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