Research ArticleCancer

Lung cancer–associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell–immune cell cross-talk

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Science Translational Medicine  15 Nov 2017:
Vol. 9, Issue 416, eaai9048
DOI: 10.1126/scitranslmed.aai9048

A tense environment

Lung cancer remains the most common cause of death worldwide, but some of the biology underlying the symptoms of this disease is still not well understood. In particular, the frequent occurrence of dyspnea in patients with advanced lung cancer remained to be explained. Pullamsetti et al. demonstrated that lung cancer drives vascular remodeling in its microenvironment, resulting in the development of pulmonary hypertension, helping to explain the patients’ symptoms. The authors showed evidence of this phenomenon in human patients, as well as in three different mouse models, where they also examined the mechanism underlying this condition.