Research ArticleHeart Failure

Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH

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Science Translational Medicine  08 Nov 2017:
Vol. 9, Issue 415, eaam8574
DOI: 10.1126/scitranslmed.aam8574

Article Information

vol. 9 no. 415

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History: 
  • Received for publication January 27, 2017
  • Resubmitted August 1, 2017
  • Accepted for publication October 3, 2017

Author Information

  1. Atze van der Pol1,
  2. Andres Gil2,
  3. Herman H. W. Silljé1,
  4. Jasper Tromp1,3,
  5. Ekaterina S. Ovchinnikova1,4,
  6. Inge Vreeswijk-Baudoin1,
  7. Martijn Hoes1,
  8. Ibrahim J. Domian5,6,
  9. Bart van de Sluis7,
  10. Jan M. van Deursen8,
  11. Adriaan A. Voors1,
  12. Dirk J. van Veldhuisen1,
  13. Wiek H. van Gilst1,
  14. Eugene Berezikov4,
  15. Pim van der Harst1,
  16. Rudolf A. de Boer1,
  17. Rainer Bischoff2 and
  18. Peter van der Meer1,*
  1. 1Department of Cardiology, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
  2. 2Department of Pharmacy, Analytical Biochemistry, University of Groningen, 9713 AV Groningen, Netherlands.
  3. 3National Heart Centre Singapore, 169609 Singapore, Singapore.
  4. 4European Research Institute for the Biology of Aging, Laboratory of Stem Cell Regulation and Mechanisms of Regeneration, University of Groningen, 9713 AV Groningen, Netherlands.
  5. 5Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  6. 6Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  7. 7Molecular Genetics Section, Department of Pediatrics, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, Netherlands.
  8. 8Department of Pediatrics, Mayo Clinic, Rochester, MN 55905, USA.
  1. *Corresponding author. Email: p.van.der.meer{at}umcg.nl

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