Research ArticleCancer

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways

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Science Translational Medicine  25 Oct 2017:
Vol. 9, Issue 413, eaao1214
DOI: 10.1126/scitranslmed.aao1214

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The right treatments for the right mutations

A variety of mutations have been observed in cancer cells from patients with acute myeloid leukemia, but it can be difficult to know which of these mutations contribute to tumorigenesis and should therefore be targeted. To address this issue, Saito et al. isolated subpopulations of leukemic cells with specific mutations and monitored their leukemogenic capacity in immunosuppressed mice. By combining this approach with genomic analysis, the authors were able to identify mutations that drive the evolution of leukemia and figure out effective approaches to target them.