Research ArticleBrain Imaging

Functional ultrasound imaging of brain activity in human newborns

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Science Translational Medicine  11 Oct 2017:
Vol. 9, Issue 411, eaah6756
DOI: 10.1126/scitranslmed.aah6756

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(f)USIng technologies to image the newborn brain

Electroencephalography (EEG) and functional neuroimaging enable us to better understand brain functions and to detect abnormalities. However, it is challenging to use these technologies at the bedside because of their size, lack of portability, and cost. Demene et al. have developed a portable customized and noninvasive system, called fUSI (functional ultrasound imaging), that is capable of continuous video-EEG recording and fast ultrasound imaging of the brain microvasculature in newborn babies. They applied fUSI to monitor brain activity and neurovascular changes in two neonates with abnormal cortical development, demonstrating the value of fUSI for the bedside monitoring of cerebral activity in neonates.