Research ArticleLUNG INJURY

Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

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Science Translational Medicine  20 Sep 2017:
Vol. 9, Issue 408, eaah5360
DOI: 10.1126/scitranslmed.aah5360

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Starting an intercellular conversation

In a new study, Neudecker et al. show that transfer of microRNA-223 (miR-223) from neutrophils to lung alveoli helps to dampen lung inflammation and promotes the resolution of ventilator-induced lung injury in mice. The authors suggest that neutrophils secrete microRNAs in microvesicles that are then taken up by alveolar epithelial cells. They show that miR-223–deficient mice are prone to lung injury, whereas overexpression of miR-223 is protective.