Research ArticleHEREDITARY AMYLOIDOSIS

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

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Science Translational Medicine  13 Sep 2017:
Vol. 9, Issue 407, eaam7621
DOI: 10.1126/scitranslmed.aam7621

Article Information

vol. 9 no. 407

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History: 
  • Received for publication January 12, 2017
  • Resubmitted March 29, 2017
  • Accepted for publication July 21, 2017

Author Information

  1. Joseph D. Schonhoft1,2,*,
  2. Cecilia Monteiro1,2,*,
  3. Lars Plate1,2,
  4. Yvonne S. Eisele1,2,
  5. John M. Kelly2,
  6. Daniel Boland1,
  7. Christopher G. Parker1,2,3,
  8. Benjamin F. Cravatt1,2,3,
  9. Sergio Teruya4,
  10. Stephen Helmke4,
  11. Mathew Maurer4,
  12. John Berk5,
  13. Yoshiki Sekijima6,
  14. Marta Novais7,
  15. Teresa Coelho7,
  16. Evan T. Powers1 and
  17. Jeffery W. Kelly1,2,3,
  1. 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
  2. 2Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
  3. 3The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  4. 4Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
  5. 5Boston University School of Medicine, Boston, MA 02118, USA.
  6. 6Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.
  7. 7Unidade Corino de Andrade, Department of Neurosciences, Hospital de Santo António, 4099-001 Porto, Portugal.
  1. Corresponding author. Email: jkelly{at}scripps.edu
    • * These authors contributed equally to this work.

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