Research ArticleRESPIRATORY DISORDERS

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma

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Science Translational Medicine  13 Sep 2017:
Vol. 9, Issue 407, eaag2288
DOI: 10.1126/scitranslmed.aag2288

Article Information

vol. 9 no. 407

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History: 
  • Received for publication May 27, 2016
  • Accepted for publication April 10, 2017

Author Information

  1. Michaela Matthey1,
  2. Richard Roberts2,
  3. Alexander Seidinger1,
  4. Annika Simon1,
  5. Ralf Schröder3,
  6. Markus Kuschak4,
  7. Suvi Annala3,
  8. Gabriele M. König5,6,
  9. Christa E. Müller4,6,
  10. Ian P. Hall7,
  11. Evi Kostenis3,6,
  12. Bernd K. Fleischmann1,6,* and
  13. Daniela Wenzel1,*
  1. 1Institute of Physiology I, Life and Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
  2. 2Pharmacology Research Group, University Hospital of Nottingham, Nottingham, UK.
  3. 3Molecular, Cellular, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
  4. 4Pharmaceutical Institute, Institute of Pharmaceutical Chemistry I, University of Bonn, Bonn, Germany.
  5. 5Institute of Pharmaceutical Biology, University of Bonn, Bonn, Germany.
  6. 6PharmaCenter, University of Bonn, Bonn, Germany.
  7. 7Division of Respiratory Medicine, University Hospital of Nottingham, Nottingham, UK.
  1. *Corresponding author. Email: dwenzel{at}uni-bonn.de (D.W.); bernd.fleischmann{at}uni-bonn.de (B.K.F.)

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