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Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins

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Science Translational Medicine  06 Sep 2017:
Vol. 9, Issue 406, eaan5954
DOI: 10.1126/scitranslmed.aan5954

Article Information

vol. 9 no. 406

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History: 
  • Received for publication May 5, 2017
  • Accepted for publication August 7, 2017

Author Information

  1. Yongmei Xu1,
  2. Kasemsiri Chandarajoti2,3,
  3. Xing Zhang4,
  4. Vijayakanth Pagadala1,*,
  5. Wenfang Dou1,
  6. Debra Moorman Hoppensteadt5,
  7. Erica M. Sparkenbaugh2,
  8. Brian Cooley6,
  9. Sharon Daily7,
  10. Nigel S. Key2,
  11. Diana Severynse-Stevens7,
  12. Jawed Fareed5,
  13. Robert J. Linhardt4,,
  14. Rafal Pawlinski2, and
  15. Jian Liu1,
  1. 1Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
  2. 2Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  3. 3Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  4. 4Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  5. 5Department of Pathology, Loyola University Medical Center, Maywood, IL 60660, USA.
  6. 6Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  7. 7Center for Global Health, RTI International, Research Triangle Park, NC 27709, USA.
  1. Corresponding author. Email: jian_liu{at}unc.edu (J.L.); rafal_pawlinski{at}med.unc.edu (R.P.); linhar{at}rpi.edu (R.J.L.)
  • * Present address: Glycan Therapeutics LLC, Chapel Hill, NC 27599, USA.

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