Research ArticleHIV

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

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Science Translational Medicine  06 Sep 2017:
Vol. 9, Issue 406, eaal1321
DOI: 10.1126/scitranslmed.aal1321

Article Information

vol. 9 no. 406

Print ISSN: 
Online ISSN: 
  • Received for publication October 25, 2016
  • Resubmitted March 15, 2017
  • Accepted for publication August 14, 2017

Author Information

  1. Boris Julg1,2,*,
  2. Lawrence J. Tartaglia2,*,
  3. Brandon F. Keele3,
  4. Kshitij Wagh4,
  5. Amarendra Pegu5,
  6. Devin Sok6,
  7. Peter Abbink2,
  8. Stephen D. Schmidt5,
  9. Keyun Wang5,
  10. Xuejun Chen5,
  11. M. Gordon Joyce5,
  12. Ivelin S. Georgiev5,
  13. Misook Choe5,
  14. Peter D. Kwong5,
  15. Nicole A. Doria-Rose5,
  16. Khoa Le6,
  17. Mark K. Louder5,
  18. Robert T. Bailer5,
  19. Penny L. Moore7,8,
  20. Bette Korber4,
  21. Michael S. Seaman2,
  22. Salim S. Abdool Karim8,9,
  23. Lynn Morris7,8,
  24. Richard A. Koup5,
  25. John R. Mascola5,
  26. Dennis R. Burton1,6 and
  27. Dan H. Barouch1,2,
  1. 1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.
  2. 2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.
  3. 3AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
  4. 4Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
  5. 5Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
  6. 6The Scripps Research Institute, La Jolla, CA 92037, USA.
  7. 7National Institute for Communicable Diseases of the National Health Laboratory Service and the University of the Witwatersrand, 2131 Johannesburg, South Africa.
  8. 8Centre for the AIDS Programme of Research in South Africa, 4013 Durban, South Africa.
  9. 9Columbia University, New York, NY 10032, USA.
  1. Corresponding author. Email: dbarouch{at}
    • * These authors contributed equally to this work.


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