Research ArticleCancer

Direct detection of early-stage cancers using circulating tumor DNA

See allHide authors and affiliations

Science Translational Medicine  16 Aug 2017:
Vol. 9, Issue 403, eaan2415
DOI: 10.1126/scitranslmed.aan2415

Article Information

vol. 9 no. 403

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 16, 2017
  • Resubmitted May 13, 2017
  • Accepted for publication July 22, 2017

Author Information

  1. Jillian Phallen1,
  2. Mark Sausen2,
  3. Vilmos Adleff1,
  4. Alessandro Leal1,
  5. Carolyn Hruban1,
  6. James White1,
  7. Valsamo Anagnostou1,
  8. Jacob Fiksel1,
  9. Stephen Cristiano1,
  10. Eniko Papp1,*,
  11. Savannah Speir1,
  12. Thomas Reinert3,
  13. Mai-Britt Worm Orntoft3,
  14. Brian D. Woodward4,
  15. Derek Murphy2,
  16. Sonya Parpart-Li2,
  17. David Riley2,
  18. Monica Nesselbush2,
  19. Naomi Sengamalay2,
  20. Andrew Georgiadis2,
  21. Qing Kay Li1,
  22. Mogens Rørbæk Madsen5,
  23. Frank Viborg Mortensen6,
  24. Joost Huiskens7,8,
  25. Cornelis Punt8,
  26. Nicole van Grieken9,
  27. Remond Fijneman10,
  28. Gerrit Meijer10,
  29. Hatim Husain4,
  30. Robert B. Scharpf1,
  31. Luis A. Diaz Jr1,,
  32. Siân Jones2,
  33. Sam Angiuoli2,
  34. Torben Ørntoft3,
  35. Hans Jørgen Nielsen11,
  36. Claus Lindbjerg Andersen3 and
  37. Victor E. Velculescu1,
  1. 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  2. 2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
  3. 3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
  4. 4Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
  5. 5Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.
  6. 6Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
  7. 7Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  8. 8Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  9. 9Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.
  10. 10Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
  11. 11Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
  1. Corresponding author. Email: velculescu{at}jhmi.edu
  • * Present address: Personal Genome Diagnostics, Baltimore, MD 21224, USA.

  • Present address: Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Altmetric

Article usage

Article usage: August 2017 to November 2017

AbstractFullPdf
Aug 201729847968113510
Sep 201774076901050
Oct 20173130459569
Nov 20171399153203