Contents

16 August 2017
Vol 9, Issue 403

  • Research Articles

    • Direct detection of early-stage cancers using circulating tumor DNA

      By Jillian Phallen, Mark Sausen, Vilmos Adleff, Alessandro Leal, Carolyn Hruban, James White, Valsamo Anagnostou, Jacob Fiksel, Stephen Cristiano, Eniko Papp, Savannah Speir, Thomas Reinert, Mai-Britt Worm Orntoft, Brian D. Woodward, Derek Murphy, Sonya Parpart-Li, David Riley, Monica Nesselbush, Naomi Sengamalay, Andrew Georgiadis, Qing Kay Li, Mogens Rørbæk Madsen, Frank Viborg Mortensen, Joost Huiskens, Cornelis Punt, Nicole van Grieken, Remond Fijneman, Gerrit Meijer, Hatim Husain, Robert B. Scharpf, Luis A. Diaz, Jr, Siân Jones, Sam Angiuoli, Torben Ørntoft, Hans Jørgen Nielsen, Claus Lindbjerg Andersen, Victor E. Velculescu

      Science Translational Medicine

      Noninvasive liquid biopsy analysis of circulating tumor DNA permits direct detection of early-stage cancers.

    • Metabolic differentiation of early Lyme disease from southern tick–associated rash illness (STARI)

      By Claudia R. Molins, Laura V. Ashton, Gary P. Wormser, Barbara G. Andre, Ann M. Hess, Mark J. Delorey, Mark A. Pilgard, Barbara J. Johnson, Kristofor Webb, M. Nurul Islam, Adoracion Pegalajar-Jurado, Irida Molla, Mollie W. Jewett, John T. Belisle

      Science Translational Medicine

      Metabolic profiling provides a biochemical signature to objectively differentiate two illnesses with nearly identical clinical presentations, early Lyme disease and STARI.

    • Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

      By Claire E. Le Pichon, William J. Meilandt, Sara Dominguez, Hilda Solanoy, Han Lin, Hai Ngu, Alvin Gogineni, Arundhati Sengupta Ghosh, Zhiyu Jiang, Seung-Hye Lee, Janice Maloney, Vineela D. Gandham, Christine D. Pozniak, Bei Wang, Sebum Lee, Michael Siu, Snahel Patel, Zora Modrusan, Xingrong Liu, York Rudhard, Miriam Baca, Amy Gustafson, Josh Kaminker, Richard A. D. Carano, Eric J. Huang, Oded Foreman, Robby Weimer, Kimberly Scearce-Levie, Joseph W. Lewcock

      Science Translational Medicine

      Blocking dual leucine zipper kinase slows disease progression in animal models of ALS and Alzheimer’s disease.

    • mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

      By Rocco G. Gogliotti, Rebecca K. Senter, Nicole M. Fisher, Jeffrey Adams, Rocio Zamorano, Adam G. Walker, Anna L. Blobaum, Darren W. Engers, Corey R. Hopkins, J. Scott Daniels, Carrie K. Jones, Craig W. Lindsley, Zixiu Xiang, P. Jeffrey Conn, Colleen M. Niswender

      Science Translational Medicine

      mGlu7 positive allosteric modulation rescues long-term potentiation, learning, and memory phenotypes and prevents apneas in a mouse model of Rett syndrome.

  • Editors' Choice

More From Science Translational Medicine

About The Cover

Cover image expansion

ONLINE COVER Turning Back the Clock to Detect Cancer. Tumors shed DNA into patients' blood, where it can be detected, but the amount of DNA is very small early in the course of disease and only increases as the tumor grows. As a result, early tumors that are easier to treat can be difficult or impossible to detect by analyzing circulating tumor DNA. As illustrated in this image, Phallen et al. have developed a method that allows more sensitive detection of smaller amounts of circulating tumor DNA, thereby "turning back the clock" and potentially permitting earlier detection of developing tumors. [CREDIT: CAROLYN HRUBAN, JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE]