Research ArticleAutoimmunity

Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

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Science Translational Medicine  09 Aug 2017:
Vol. 9, Issue 402, eaaf7779
DOI: 10.1126/scitranslmed.aaf7779

Article Information

vol. 9 no. 402

Print ISSN: 
Online ISSN: 
  • Received for publication March 29, 2016
  • Resubmitted April 13, 2017
  • Accepted for publication July 11, 2017

Author Information

  1. Mohammad Alhadj Ali1,*,
  2. Yuk-Fun Liu2,3,*,
  3. Sefina Arif2,
  4. Danijela Tatovic1,
  5. Hina Shariff2,
  6. Vivienne B. Gibson2,
  7. Norkhairin Yusuf2,
  8. Roman Baptista2,4,
  9. Martin Eichmann2,
  10. Nedyalko Petrov4,
  11. Susanne Heck4,
  12. Jennie H. M. Yang2,
  13. Timothy I. M. Tree2,
  14. Irma Pujol-Autonell2,
  15. Lorraine Yeo2,
  16. Lucas R. Baumard2,
  17. Rachel Stenson1,
  18. Alex Howell1,
  19. Alison Clark1,
  20. Zoe Boult5,
  21. Jake Powrie3,
  22. Laura Adams3,
  23. Florence S. Wong1,
  24. Stephen Luzio6,
  25. Gareth Dunseath6,
  26. Kate Green7,
  27. Alison O’Keefe7,
  28. Graham Bayly7,
  29. Natasha Thorogood7,
  30. Robert Andrews7,
  31. Nicola Leech8,
  32. Frank Joseph9,
  33. Sunil Nair9,
  34. Susan Seal9,
  35. HoYee Cheung9,
  36. Craig Beam10,
  37. Robert Hills11,
  38. Mark Peakman2,4,12,, and
  39. Colin M. Dayan1,
  1. 1Diabetes Research Group, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
  2. 2Department of Immunobiology, Faculty of Life Sciences and Medicine, King’s College London, London SE19RT, UK.
  3. 3Department of Diabetes and Endocrinology, Guy’s and St Thomas’ Hospital National Health Service (NHS) Foundation Trust, London SE19RT, UK.
  4. 4National Institute of Health Research Biomedical Research Centre at Guy’s and St Thomas’ Hospital and King’s College London, London SE19RT, UK.
  5. 5Clinical Research Facility, University Hospital of Wales, Cardiff CF14 4XN, UK.
  6. 6Diabetes Research Unit Cymru, Swansea University, Swansea SA2 8PP, UK.
  7. 7Joint Clinical Research Unit, University Hospitals Bristol Foundation Trust, Bristol BS2 8HW, UK.
  8. 8Diabetes and Endocrinology Department, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle NE1 4LP, UK.
  9. 9Diabetes and Endocrinology Department, Countess of Chester Hospital NHS Foundation Trust, Chester CH2 1UL, UK.
  10. 10Division of Epidemiology and Biostatistics, Western Michigan University School of Medicine, MI 49008, USA.
  11. 11Haematology Clinical Trials Unit, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
  12. 12King’s Health Partners Institute of Diabetes, Endocrinology and Obesity, London SE19RT, UK.
  1. Corresponding author. Email: mark.peakman{at}
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.


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