Contents

07 June 2017
Vol 9, Issue 393

About The Cover

Cover image expansion

ONLINE COVER Teaming Up Against Breast Cancer. Breast cancer is generally difficult to treat with immunotherapy, even for tumors with high numbers of potentially immunogenic mutations, such as those with mutant BRCA1, a protein involved in DNA repair. Nolan et al. determined that successful immunotherapy against BRCA1-mutated tumors, such as the one shown in the image, requires a combination approach, and demonstrated the effectiveness of combining two immune checkpoint inhibitors and DNA-damaging chemotherapy in this cancer type. [CREDIT: NOLAN ET AL./SCIENCE TRANSLATIONAL MEDICINE; H.M. HALSE]