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Research ArticleNanomedicine
Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
- Miles A. Miller1,2,
- Ravi Chandra1,3,
- Michael F. Cuccarese1,
- Christina Pfirschke1,
- Camilla Engblom1,
- Shawn Stapleton1,
- Utsarga Adhikary1,
- Rainer H. Kohler1,
- James F. Mohan1,
- Mikael J. Pittet1,2 and
- Ralph Weissleder1,2,4,*
- 1Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
- 2Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
- 3Harvard Radiation Oncology Program, 55 Fruit Street, Boston, MA 02114, USA.
- 4Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
- ↵*Corresponding author. Email: rweissleder{at}mgh.harvard.edu
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Science Translational Medicine 31 May 2017:
Vol. 9, Issue 392, eaal0225
DOI: 10.1126/scitranslmed.aal0225
Vol. 9, Issue 392, eaal0225
DOI: 10.1126/scitranslmed.aal0225
Miles A. Miller
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Ravi Chandra
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.Harvard Radiation Oncology Program, 55 Fruit Street, Boston, MA 02114, USA.
Michael F. Cuccarese
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Christina Pfirschke
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Camilla Engblom
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Shawn Stapleton
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Utsarga Adhikary
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Rainer H. Kohler
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
James F. Mohan
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.
Mikael J. Pittet
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Ralph Weissleder
Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
