Contents
17 May 2017
Vol 9, Issue 390
Vol 9, Issue 390
Research Articles
- BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.
- In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
Microbubble-enhanced, ultrasound-mediated BMP-6 gene delivery to endogenous progenitor cells induces rapid and efficient repair of critical-sized, nonunion bone fractures in mini-pigs.
- The effects of micronutrient deficiencies on bacterial species from the human gut microbiota
Mechanistic studies reveal pronounced effects of vitamin A deficiency on bacterial members of a defined human gut microbiota.
- Central-acting therapeutics alleviate respiratory weakness caused by heart failure–induced ventilatory overdrive
Drugs that penetrate the blood-brain barrier normalize ventilatory function and prevent diaphragm atrophy in heart failure.
Editors' Choice
- Hung over? Maybe it’s your overactive microglia
Acute ethanol intake is associated with a mild suppression of microglial activity followed by a more robust inflammatory reaction during the withdrawal period.
- An “eye” for rhythm
A new analytical method allows reconstruction of circadian gene expression in human biopsy samples.
- Chemotherapy-treated cells go up in flames
Apoptosis induced by chemotherapies can also trigger proinflammatory pyroptosis.
- Turning back the clock
Increased DNA breaks in aging skeletal muscle activate the DNA-PK pathway, whereas blocking this pathway improves mitochondrial density, physical fitness, body weight, and insulin resistance in mice.
About The Cover
ONLINE COVER Taking Bromodomains to Heart. Bromodomain proteins are epigenetic "readers" that are usually associated with cancer progression. Duan et al. determined that a bromodomain protein called BRD4 (featured inside the heart in this image) plays a role in heart failure as well and demonstrated the effectiveness of a BRD4 inhibitor in mouse models of this disease. [CREDIT: IMAGE CONCEPT: S. HALDAR/GLADSTONE INSTITUTES, S. PYLE, AND G. GRULLÓN/SCIENCE TRANSLATIONAL MEDICINE; PROTEIN STRUCTURE REPRODUCED FROM P. FILIPPAKOPOULOS ET AL., NATURE, 468 (2010) WITH PERMISSION FROM NATURE PUBLISHING GROUP; HEART IMAGE: DEVRHIMB/ISTOCKPHOTO]