Image concept: S. Haldar/Gladstone Institutes, S. Pyle, and G. Grullón/Science Translational Medicine; protein structure reproduced from P. Filippakopoulos et al., Nature, 468 (2010) with permission from Nature Publishing Group; Heart image: Devrhimb/istockphoto
Vol 9, Issue 390
- BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.
- In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs
Microbubble-enhanced, ultrasound-mediated BMP-6 gene delivery to endogenous progenitor cells induces rapid and efficient repair of critical-sized, nonunion bone fractures in mini-pigs.
Mechanistic studies reveal pronounced effects of vitamin A deficiency on bacterial members of a defined human gut microbiota.
- Central-acting therapeutics alleviate respiratory weakness caused by heart failure–induced ventilatory overdrive
Drugs that penetrate the blood-brain barrier normalize ventilatory function and prevent diaphragm atrophy in heart failure.
Acute ethanol intake is associated with a mild suppression of microglial activity followed by a more robust inflammatory reaction during the withdrawal period.
Increased DNA breaks in aging skeletal muscle activate the DNA-PK pathway, whereas blocking this pathway improves mitochondrial density, physical fitness, body weight, and insulin resistance in mice.