Editors' ChoiceAging

Turning back the clock

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Science Translational Medicine  17 May 2017:
Vol. 9, Issue 390, eaan4290
DOI: 10.1126/scitranslmed.aan4290

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Increased DNA breaks in aging skeletal muscle activate the DNA-PK pathway, whereas blocking this pathway improves mitochondrial density, physical fitness, body weight, and insulin resistance in mice.

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