Research ArticleBone Regeneration

In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

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Science Translational Medicine  17 May 2017:
Vol. 9, Issue 390, eaal3128
DOI: 10.1126/scitranslmed.aal3128

Article Information

vol. 9 no. 390

PubMed: 
Print ISSN: 
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History: 
  • Received for publication November 3, 2016
  • Resubmitted February 8, 2017
  • Accepted for publication April 14, 2017

Author Information

  1. Maxim Bez1,2,
  2. Dmitriy Sheyn2,3,
  3. Wafa Tawackoli2,3,4,5,
  4. Pablo Avalos3,
  5. Galina Shapiro1,
  6. Joseph C. Giaconi6,
  7. Xiaoyu Da4,
  8. Shiran Ben David2,3,
  9. Jayne Gavrity7,
  10. Hani A. Awad7,
  11. Hyun W. Bae2,
  12. Eric J. Ley2,
  13. Thomas J. Kremen2,8,
  14. Zulma Gazit1,2,3,8,
  15. Katherine W. Ferrara9,
  16. Gadi Pelled1,2,3,4,5,* and
  17. Dan Gazit1,2,3,4,5,8,*,
  1. 1Skeletal Biotech Laboratory, Hadassah Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem 91120, Israel.
  2. 2Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
  3. 3Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  4. 4Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  5. 5Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  6. 6Department of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  7. 7Department of Biomedical Engineering and the Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA.
  8. 8Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  9. 9Department of Biomedical Engineering, University of California, Davis, 451 Health Sciences Drive, Davis, CA 95616, USA.
  1. Corresponding author. Email: dan.gazit{at}csmc.edu
    • * These authors contributed equally to this work.

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