Contents

17 May 2017
Vol 9, Issue 390

About The Cover

Cover image expansion

ONLINE COVER Taking Bromodomains to Heart. Bromodomain proteins are epigenetic "readers" that are usually associated with cancer progression. Duan et al. determined that a bromodomain protein called BRD4 (featured inside the heart in this image) plays a role in heart failure as well and demonstrated the effectiveness of a BRD4 inhibitor in mouse models of this disease. [CREDIT: IMAGE CONCEPT: S. HALDAR/GLADSTONE INSTITUTES, S. PYLE, AND G. GRULLÓN/SCIENCE TRANSLATIONAL MEDICINE; PROTEIN STRUCTURE REPRODUCED FROM P. FILIPPAKOPOULOS ET AL., NATURE, 468 (2010) WITH PERMISSION FROM NATURE PUBLISHING GROUP; HEART IMAGE: DEVRHIMB/ISTOCKPHOTO]